PMID- 23917746
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20140212
IS  - 1572-8781 (Electronic)
IS  - 1387-2176 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Feb
TI  - Interdigitated silver-polymer-based antibacterial surface system activated by 
      oligodynamic iontophoresis - an empirical characterization study.
PG  - 1-10
LID - 10.1007/s10544-013-9800-x [doi]
AB  - There is a pressing need to control the occurrences of nosocomial infections due 
      to their detrimental effects on patient well-being and the rising treatment 
      costs. To prevent the contact transmission of such infections via health-critical 
      surfaces, a prophylactic surface system that consists of an interdigitated array 
      of oppositely charged silver electrodes with polymer separations and utilizes 
      oligodynamic iontophoresis has been recently developed. This paper presents a 
      systematic study that empirically characterizes the effects of the surface system 
      parameters on its antibacterial efficacy, and validates the system's 
      effectiveness. In the first part of the study, a fractional factorial design of 
      experiments (DOE) was conducted to identify the statistically significant system 
      parameters. The data were used to develop a first-order response surface model to 
      predict the system's antibacterial efficacy based on the input parameters. In the 
      second part of the study, the effectiveness of the surface system was validated 
      by evaluating it against four bacterial species responsible for several 
      nosocomial infections - Staphylococcus aureus, Escherichia coli, Pseudomonas 
      aeruginosa, and Enterococcus faecalis - alongside non-antibacterial polymer 
      (acrylic) control surfaces. The system demonstrated statistically significant 
      efficacy against all four bacteria. The results indicate that given a constant 
      total effective surface area, the system designed with micro-scale features 
      (minimum feature width: 20 mum) and activated by 15 muA direct current will provide 
      the most effective antibacterial prophylaxis.
FAU - Shirwaiker, Rohan A
AU  - Shirwaiker RA
AD  - Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina 
      State University, 400 Daniels Hall, Raleigh, NC, 27695-7906, USA, 
      rashirwaiker@ncsu.edu.
FAU - Wysk, Richard A
AU  - Wysk RA
FAU - Kariyawasam, Subhashinie
AU  - Kariyawasam S
FAU - Voigt, Robert C
AU  - Voigt RC
FAU - Carrion, Hector
AU  - Carrion H
FAU - Nembhard, Harriet Black
AU  - Nembhard HB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biomed Microdevices
JT  - Biomedical microdevices
JID - 100887374
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Polymers)
RN  - 3M4G523W1G (Silver)
SB  - IM
MH  - Anti-Bacterial Agents/*chemistry
MH  - Cross Infection/prevention & control
MH  - Enterococcus faecalis/drug effects
MH  - Escherichia coli/drug effects
MH  - Humans
MH  - Iontophoresis/*methods
MH  - Polymers/*chemistry
MH  - Pseudomonas aeruginosa/drug effects
MH  - Silver/*chemistry
MH  - Staphylococcus aureus/drug effects
EDAT- 2013/08/07 06:00
MHDA- 2014/09/30 06:00
CRDT- 2013/08/07 06:00
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - 10.1007/s10544-013-9800-x [doi]
PST - ppublish
SO  - Biomed Microdevices. 2014 Feb;16(1):1-10. doi: 10.1007/s10544-013-9800-x.