PMID- 23917811
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20231213
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 10
IP  - 8
DP  - 2013 Aug 2
TI  - Hypothyroxinemia induced by mild iodine deficiency deregulats thyroid proteins 
      during gestation and lactation in dams.
PG  - 3233-45
LID - 10.3390/ijerph10083233 [doi]
AB  - The main object of the present study was to explore the effect on thyroidal 
      proteins following mild iodine deficiency (ID)-induced maternal hypothyroxinemia 
      during pregnancy and lactation. In the present study, we established a maternal 
      hypothyroxinemia model in female Wistar rats by using a mild ID diet. Maternal 
      thyroid iodine content and thyroid weight were measured. Expressions of 
      thyroid-associated proteins were analyzed. The results showed that the mild ID 
      diet increased thyroid weight, decreased thyroid iodine content and increased 
      expressions of thyroid transcription factor 1, paired box gene 8 and Na+/I- 
      symporter on gestational day (GD) 19 and postpartum days (PN) 21 in the maternal 
      thyroid. Moreover, the up-regulated expressions of type 1 iodothyronine 
      deiodinase (DIO1) and type 2 iodothyronine deiodinase (DIO2) were detected in the 
      mild ID group on GD19 and PN21. Taken together, our data indicates that during 
      pregnancy and lactation, a maternal mild ID could induce hypothyroxinemia and 
      increase the thyroidal DIO1 and DIO2 levels.
FAU - Wei, Wei
AU  - Wei W
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      China Medical University, 92 North 2nd Road, Shenyang 110001, China. 
      weiwei840403@163.com
FAU - Wang, Yi
AU  - Wang Y
FAU - Dong, Jing
AU  - Dong J
FAU - Wang, Yuan
AU  - Wang Y
FAU - Min, Hui
AU  - Min H
FAU - Song, Binbin
AU  - Song B
FAU - Shan, Zhongyan
AU  - Shan Z
FAU - Teng, Weiping
AU  - Teng W
FAU - Xi, Qi
AU  - Xi Q
FAU - Chen, Jie
AU  - Chen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130802
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (NKX2-1 protein, human)
RN  - 0 (Nkx2-1 protein, rat)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PAX8 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Pax8 protein, rat)
RN  - 0 (Symporters)
RN  - 0 (Thyroid Nuclear Factor 1)
RN  - 0 (Transcription Factors)
RN  - 4XE5NDT4K1 (sodium-iodide symporter)
RN  - 9679TC07X4 (Iodine)
RN  - EC 1.11.1.- (iodothyronine deiodinase type I)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Gene Expression Regulation
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Hypothyroidism/chemically induced/metabolism
MH  - Iodide Peroxidase/genetics/metabolism
MH  - Iodine/*deficiency
MH  - Lactation/*metabolism
MH  - Nuclear Proteins/genetics/metabolism
MH  - Organ Size
MH  - PAX8 Transcription Factor
MH  - Paired Box Transcription Factors/genetics/metabolism
MH  - Pregnancy
MH  - Pregnancy Complications/genetics/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Symporters/genetics/metabolism
MH  - Thyroid Gland/*metabolism/physiology
MH  - Thyroid Nuclear Factor 1
MH  - Thyroxine/*blood
MH  - Transcription Factors/genetics/metabolism
MH  - Iodothyronine Deiodinase Type II
PMC - PMC3774435
EDAT- 2013/08/07 06:00
MHDA- 2014/02/04 06:00
PMCR- 2013/08/01
CRDT- 2013/08/07 06:00
PHST- 2013/06/21 00:00 [received]
PHST- 2013/07/24 00:00 [revised]
PHST- 2013/07/26 00:00 [accepted]
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - ijerph10083233 [pii]
AID - ijerph-10-03233 [pii]
AID - 10.3390/ijerph10083233 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2013 Aug 2;10(8):3233-45. doi: 
      10.3390/ijerph10083233.