PMID- 23918775
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20220408
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Jan
TI  - Inflammatory cytokines in chronic heart failure: interleukin-8 is associated with 
      adverse outcome. Results from CORONA.
PG  - 68-75
LID - 10.1093/eurjhf/hft125 [doi]
AB  - AIM: We investigated the ability of prototypical inflammatory cytokines to 
      predict clinical outcomes in a large population of patients with chronic systolic 
      heart failure (HF). METHODS AND RESULTS: Serum levels of tumour necrosis factor-alpha 
      (TNF-alpha), soluble TNF receptors type I and II (sTNF-RI and sTNF-RII), and the 
      chemokines monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) 
      were analysed in 1464 patients with chronic ischaemic systolic HF in the CORONA 
      study, aged >/= 60 years, in NYHA class II-IV, and related to the primary endpoint 
      (n = 320), as well as any coronary event (n = 255), all-cause mortality (n = 
      329), cardiovascular (CV) mortality (n = 268), and the composite endpoint 
      hospitalization from worsening heart failure (WHF) or CV mortality (n = 547). 
      TNF-alpha, sTNF-RI, sTNF-RII, and IL-8, but not MCP-1, were independent predictors of 
      all endpoints except the coronary endpoint in multivariable models including 
      conventional clinical variables. After further adjustment for estimated 
      glomerular filtration rate, the ApoB/ApoA-1 ratio, NT-proBNP, and 
      high-sensitivity C-reactive protein, only IL-8 remained a significant predictor 
      of all endpoints (except the coronary endpoint), while sTNF- RI remained 
      independently associated with CV mortality. Adding IL-8 to the full model led to 
      a significant improvement in net reclassification for all-cause mortality and CV 
      hospitalization, but only a borderline significant improvement for the primary 
      endpoint, CV mortality, and the composite endpoint WHF hospitalization or CV 
      mortality. CONCLUSION: Our study supports a relationship between IL-8 and 
      outcomes in patients with chronic HF. However, the clinical usefulness of IL-8 as 
      a biomarker in an unselected HF population is at present unclear.
CI  - First published online by Oxford University Press on behalf of the European 
      Society of Cardiology. All rights reserved. (c) The Author 2013.
FAU - Nymo, Stale H
AU  - Nymo SH
AD  - Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, 
      Oslo, Norway; Center for Heart Failure Research, University of Oslo, Oslo, 
      Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
FAU - Hulthe, Johannes
AU  - Hulthe J
FAU - Ueland, Thor
AU  - Ueland T
FAU - McMurray, John
AU  - McMurray J
FAU - Wikstrand, John
AU  - Wikstrand J
FAU - Askevold, Erik T
AU  - Askevold ET
FAU - Yndestad, Arne
AU  - Yndestad A
FAU - Gullestad, Lars
AU  - Gullestad L
FAU - Aukrust, Pal
AU  - Aukrust P
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20131203
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Biomarkers
MH  - Cytokines/*blood
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/complications
MH  - Humans
MH  - Inflammation/*blood/complications
MH  - Interleukin-8/blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Heart failure
OT  - Inflammation
OT  - Interleukins
OT  - Prognosis
OT  - Survival
EDAT- 2013/08/07 06:00
MHDA- 2014/10/29 06:00
CRDT- 2013/08/07 06:00
PHST- 2013/05/22 00:00 [received]
PHST- 2013/06/04 00:00 [accepted]
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
AID - hft125 [pii]
AID - 10.1093/eurjhf/hft125 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2014 Jan;16(1):68-75. doi: 10.1093/eurjhf/hft125. Epub 2013 Dec 
      3.