PMID- 23919529
OWN - NLM
STAT- MEDLINE
DCOM- 20140808
LR  - 20190619
IS  - 1365-2443 (Electronic)
IS  - 1356-9597 (Linking)
VI  - 18
IP  - 11
DP  - 2013 Nov
TI  - Golden goal controls dendrite elongation and branching of multidendritic 
      arborization neurons in Drosophila.
PG  - 960-73
LID - 10.1111/gtc.12089 [doi]
AB  - Precise refinement of axonal and dendritic patterns is essential for the 
      maturation of functional neuronal circuits. Although several transmembrane 
      molecules have been shown to control the development of both axons and dendrites, 
      the molecular mechanisms that regulate these different processes are poorly 
      understood. Golden Goal (Gogo) is one of the molecules that are known to control 
      the development of axons in the Drosophila visual system. In this study, we 
      analyzed Gogo function in dendritic field formation of dorsal multidendritic 
      arborization (md-da) neurons of the Drosophila Peripheral Nervous System. We 
      showed that Gogo is required to restrain the growth of ddaC dendrites toward the 
      midline in the embryo. During larval stages, Gogo promotes dendritic branching of 
      the complex classIV ddaC neurons. However, over-expression of Gogo restrained 
      dendritic branch formation in ddaC neurons, and this phenotype was enhanced by 
      co-over-expression with Flamingo (Fmi), a partner of Gogo in axon guidance. These 
      results suggest Gogo plays important roles in maintaining homeostasis of 
      dendritic branching. Like axons, the cytoplasmic part of Gogo is required for its 
      function in dendritic tree formation, suggesting that Gogo conveys information 
      from extracellular cues to intracellular molecules that control dendrite 
      development.
CI  - (c) 2013 The Authors Genes to Cells (c) 2013 by the Molecular Biology Society of 
      Japan and Wiley Publishing Asia Pty Ltd.
FAU - Hakeda, Satoko
AU  - Hakeda S
AD  - Max Planck Institute of Neurobiology, Am Klopferspitz 18, Martinsried, 82152, 
      Germany; Tokyo Institute of Technology, Graduate School of Bioscience & 
      Biotechnology, Nagatsuta 4259, Midoriku, Yokohama, 226-8501, Japan.
FAU - Suzuki, Takashi
AU  - Suzuki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130806
PL  - England
TA  - Genes Cells
JT  - Genes to cells : devoted to molecular & cellular mechanisms
JID - 9607379
RN  - 0 (Cadherins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Gogo protein, Drosophila)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (stan protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Cadherins/genetics/metabolism
MH  - Dendrites/*physiology
MH  - Drosophila/*cytology/embryology/growth & development
MH  - Drosophila Proteins/genetics/metabolism
MH  - Eye Proteins/genetics/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Larva/cytology/genetics/metabolism
MH  - Morphogenesis
MH  - Mutation
MH  - Neurons/*physiology
MH  - Phenotype
MH  - Receptors, Cell Surface/genetics/*metabolism
EDAT- 2013/08/08 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/08/08 06:00
PHST- 2013/05/21 00:00 [received]
PHST- 2013/07/03 00:00 [accepted]
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - 10.1111/gtc.12089 [doi]
PST - ppublish
SO  - Genes Cells. 2013 Nov;18(11):960-73. doi: 10.1111/gtc.12089. Epub 2013 Aug 6.