PMID- 23919616
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20161125
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 32
IP  - 10
DP  - 2013 Oct
TI  - Association of APOA5 -1131T>C polymorphism and serum lipid levels in patients 
      with type 2 diabetes.
PG  - 589-93
LID - 10.1089/dna.2013.2099 [doi]
AB  - Significant abnormalities in lipid metabolism are frequently present in patients 
      with type 2 diabetes mellitus (T2DM). Hypertriglyceridemia, a highly 
      proatherogenic state, is associated with increased risk of coronary artery 
      disease. Genetic polymorphism APOA5 -1131T>C has been recognized as a significant 
      contributor to hypertriglyceridemia in both healthy and diabetic populations. The 
      aim of the study was to investigate the association of APOA5 -1131T>C 
      polymorphism with the serum levels of triglycerides, total cholesterol, 
      high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) 
      cholesterol in patients with T2DM. In total, 234 DNA samples from patients with 
      T2DM were genotyped using the PCR-RFLP method. Serum lipid levels were measured 
      using standard laboratory methods. Obtained APOA5 -1131T>C genotype frequencies 
      were 89% (T/T) and 11% (T/C+C/C). There was no significant association between 
      APOA5 -1131T>C genotypes and triglyceride levels (1.90 mM [1.32-2.74] vs. 1.78 mM 
      [1.54-3.05] for T/T vs. T/C+C/C genotype; p=0.553), HDL cholesterol levels 
      (1.30 mM [1.10-1.40] vs. 1.30 mM [1.05-1.40] for T/T vs. T/C+C/C; p=0.534), and 
      LDL cholesterol levels (3.1 mM [2.3-3.8] vs. 3.0 mM [2.2-3.5] for T/T vs. 
      T/C+C/C; p=0.313). Our results suggest that hypertriglyceridemia in patients with 
      T2DM is not likely to be associated with the APOA5 -1131T>C polymorphism.
FAU - Celap, Ivana
AU  - Celap I
AD  - 1 University Department of Chemistry, Medical School University Hospital Sestre 
      Milosrdnice , Zagreb, Croatia .
FAU - Simundic, Ana-Maria
AU  - Simundic AM
FAU - Nikolac, Nora
AU  - Nikolac N
FAU - Kackov, Sanja
AU  - Kackov S
FAU - Katalinic, Darko
AU  - Katalinic D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130806
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (APOA5 protein, human)
RN  - 0 (Apolipoprotein A-V)
RN  - 0 (Apolipoproteins A)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoprotein A-V
MH  - Apolipoproteins A/*genetics
MH  - Diabetes Mellitus, Type 2/*blood/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2013/08/08 06:00
MHDA- 2013/11/19 06:00
CRDT- 2013/08/08 06:00
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - 10.1089/dna.2013.2099 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2013 Oct;32(10):589-93. doi: 10.1089/dna.2013.2099. Epub 2013 Aug 
      6.