PMID- 23919748
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20220331
IS  - 1875-5992 (Electronic)
IS  - 1871-5206 (Linking)
VI  - 13
IP  - 8
DP  - 2013 Oct
TI  - Omega-3 polyunsaturated fatty acids and cancer.
PG  - 1162-77
AB  - While the anticancer effect of omega-3 polyunsaturated fatty acids (omega-3 fatty 
      acids), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), 
      has been the subject of intense study, our understanding regarding the underlying 
      mechanisms of omega-3 fatty acids against cancer is still limited. Recent studies 
      describing the cancer protective effect of EPA and DHA have sparked a renewed 
      interest in using these fatty acids for cancer prevention and treatment. Here, we 
      summarize the significance of omega- 3 fatty acids in the initiation and 
      progression of cancer, and review the complex mechanisms by which EPA and DHA are 
      thought to have anticancer activities during cancer development. It is concluded 
      that omega-3 fatty acids may exert their anticancer actions by influencing 
      multiple targets implicated in various stages of cancer development, including 
      cell proliferation, cell survival, angiogenesis, inflammation, metastasis and 
      epigenetic abnormalities that are crucial to the onset and progression of cancer.
FAU - Jing, Kaipeng
AU  - Jing K
AD  - Department of Biochemistry, College of Medicine, Chungnam National University, 
      Daejeon, 301-747, Korea.
FAU - Wu, Tong
AU  - Wu T
FAU - Lim, Kyu
AU  - Lim K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Anticancer Agents Med Chem
JT  - Anti-cancer agents in medicinal chemistry
JID - 101265649
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/administration & dosage/pharmacology
MH  - Cell Proliferation/drug effects
MH  - Docosahexaenoic Acids/administration & dosage/metabolism/*pharmacology
MH  - Eicosapentaenoic Acid/administration & dosage/metabolism/pharmacology
MH  - Fatty Acids, Omega-3/administration & dosage/*metabolism/*pharmacology
MH  - Humans
MH  - Neoplasms/*metabolism/prevention & control
EDAT- 2013/08/08 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/08/08 06:00
PHST- 2012/07/16 00:00 [received]
PHST- 2012/12/23 00:00 [revised]
PHST- 2013/03/28 00:00 [accepted]
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - 55005 [pii]
AID - 10.2174/18715206113139990319 [doi]
PST - ppublish
SO  - Anticancer Agents Med Chem. 2013 Oct;13(8):1162-77. doi: 
      10.2174/18715206113139990319.