PMID- 23920158
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 250
DP  - 2013 Oct 10
TI  - Developmental changes in BDNF protein in the song control nuclei of zebra 
      finches.
PG  - 578-87
LID - S0306-4522(13)00656-8 [pii]
LID - 10.1016/j.neuroscience.2013.07.062 [doi]
AB  - The zebra finch song system provides an excellent model to study the mechanisms 
      underlying the development of sex difference in brain structure and function. 
      Only male zebra finches sing and the brain nuclei controlling song learning and 
      production are considerably larger than in females. Sexual differentiation may in 
      part be regulated by estrogen, but other molecules including neurotrophic factors 
      likely also affect masculinization. Brain derived neurotrophic factor (BDNF) 
      plays a crucial role in numerous aspects of vertebrate brain development and 
      function, including neurogenesis, cell survival, growth of axonal projections, 
      synaptogenesis and processes linked to learning and memory. The current study 
      investigated the expression of BDNF protein in juvenile males and females at four 
      ages, as well as in adults, to begin to evaluate the potential roles of 
      endogenous BDNF in particular stages of structural and functional development of 
      the song system. In both HVC and the robust nucleus of the arcopallium (RA), 
      males had more BDNF+ cells than females. The number of immunopositive cells 
      increased in males and decreased in females as they matured, in a pattern 
      generally consistent with a role for BDNF in sensorimotor integration of song 
      learning. In addition, in HVC (but not RA) the ratio of mature BDNF compared to 
      its precursor proBDNF was greater in adult males than those at post-hatching day 
      25, indicating a region-specific shift in the relative availability of the two 
      forms. Collectively, the data suggest that changes in BDNF protein expression 
      across development may be associated with song system maturation, particularly 
      during the sensorimotor integration of masculine vocalizations.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Tang, Y P
AU  - Tang YP
AD  - Michigan State University, Department of Psychology, East Lansing, MI 48824, USA; 
      Michigan State University, Neuroscience Program, East Lansing, MI 48824, USA. 
      Electronic address: tangyupi@msu.edu.
FAU - Wade, J
AU  - Wade J
LA  - eng
GR  - R01 MH096705/MH/NIMH NIH HHS/United States
GR  - R01-MH096705/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130803
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain/*growth & development/*physiology
MH  - Brain Chemistry/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Finches/*physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Sex Characteristics
MH  - Sex Differentiation/physiology
MH  - Vocalization, Animal/*physiology
PMC - PMC3789383
MID - NIHMS512650
OTO - NOTNLM
OT  - ANOVA
OT  - BDNF
OT  - E2
OT  - LMAN
OT  - NGS
OT  - Neurotrophic factor
OT  - PBS
OT  - PVDF
OT  - RA
OT  - Sexual differentiation
OT  - Songbird
OT  - TrkB
OT  - analysis of variance
OT  - brain-derived neurotrophic factor
OT  - estradiol
OT  - lateral magnocellular nucleus of the anterior nidopallium
OT  - mBDNF
OT  - mature BDNF
OT  - normal goat serum
OT  - p75 pan-neurotrophin receptor
OT  - p75NTR
OT  - phosphate-buffered saline
OT  - polyvinyl difluoride
OT  - robust nucleus of the arcopallium
OT  - tyrosine kinase receptors
EDAT- 2013/08/08 06:00
MHDA- 2014/04/05 06:00
PMCR- 2014/10/10
CRDT- 2013/08/08 06:00
PHST- 2013/05/02 00:00 [received]
PHST- 2013/07/25 00:00 [revised]
PHST- 2013/07/27 00:00 [accepted]
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
PHST- 2014/10/10 00:00 [pmc-release]
AID - S0306-4522(13)00656-8 [pii]
AID - 10.1016/j.neuroscience.2013.07.062 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Oct 10;250:578-87. doi: 10.1016/j.neuroscience.2013.07.062. 
      Epub 2013 Aug 3.