PMID- 23921265
OWN - NLM
STAT- MEDLINE
DCOM- 20140213
LR  - 20191210
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1306
DP  - 2013 Sep 6
TI  - Enantiomeric separation of volatile organics by gas chromatography for the in 
      situ analysis of extraterrestrial materials: kinetics and thermodynamics 
      investigation of various chiral stationary phases.
PG  - 59-71
LID - S0021-9673(13)01118-7 [pii]
LID - 10.1016/j.chroma.2013.07.058 [doi]
AB  - The performances of several commercial chiral capillary columns have been 
      evaluated with the aim of determining the one most suitable for enantiomeric 
      separation in a gas chromatograph onboard a space probe. We compared the GC-MS 
      response of three capillary columns coated with different chiral stationary 
      phases (CSP) using volatile chiral organic molecules which are potential markers 
      of a prebiotic organic chemistry. The three different chiral capillary columns 
      are Chirasil-Val, with an amino acid derivative CSP, ChiralDex-beta-PM, with a CSP 
      composed of dissolved permethylated beta-cyclodextrins in polysiloxane, and 
      Chirasil-Dex, with a CSP made of modified cyclodextrins chemically bonded to the 
      polysiloxane backbone. Both kinetics and thermodynamics studies have been carried 
      out to evaluate the chiral recognition potential in these different types of 
      columns. The thermodynamic parameters also allow a better understanding of the 
      driving forces affecting the retention and separation of the enantiomers. The 
      Chirasil-Dex-CSP displays the best characteristics for an optimal resolution of 
      the chiral compounds, without preliminary derivatization. This CSP had been 
      chosen to be the only chiral column in the Sample Analysis at Mars (SAM) 
      experiment onboard the current Mars Science Laboratory (MSL) mission, and is also 
      part of the Mars Organic Molecules Analyzer (MOMA) gas chromatograph onboard the 
      next Martian mission ExoMars. The use of this column could also be extended to 
      all space missions aimed at studying chirality in space.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Freissinet, C
AU  - Freissinet C
AD  - Laboratoire de Genie des Procedes et Materiaux (LGPM), Ecole Centrale Paris, 
      92295 Chatenay-Malabry, France. caroline.freissinet@nasa.gov
FAU - Buch, A
AU  - Buch A
FAU - Szopa, C
AU  - Szopa C
FAU - Sternberg, R
AU  - Sternberg R
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20130719
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Exobiology/instrumentation/*methods
MH  - Gas Chromatography-Mass Spectrometry/instrumentation/*methods
MH  - Kinetics
MH  - Mars
MH  - Stereoisomerism
MH  - Thermodynamics
MH  - Volatile Organic Compounds/*chemistry
OTO - NOTNLM
OT  - Chirality
OT  - Space analysis
OT  - Volatile organics
EDAT- 2013/08/08 06:00
MHDA- 2014/02/14 06:00
CRDT- 2013/08/08 06:00
PHST- 2013/03/23 00:00 [received]
PHST- 2013/07/13 00:00 [revised]
PHST- 2013/07/15 00:00 [accepted]
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2014/02/14 06:00 [medline]
AID - S0021-9673(13)01118-7 [pii]
AID - 10.1016/j.chroma.2013.07.058 [doi]
PST - ppublish
SO  - J Chromatogr A. 2013 Sep 6;1306:59-71. doi: 10.1016/j.chroma.2013.07.058. Epub 
      2013 Jul 19.