PMID- 23921568
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20220317
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 162
IP  - 2
DP  - 2013
TI  - A molecular diagnostic algorithm to guide pollen immunotherapy in southern 
      Europe: towards component-resolved management of allergic diseases.
PG  - 163-72
LID - 10.1159/000353113 [doi]
AB  - Correct identification of the culprit allergen is an essential part of diagnosis 
      and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent 
      years, molecular biology has made important advances facilitating such 
      identification and overcoming some of the drawbacks of natural allergen extracts, 
      which consist of mixtures of various proteins that may be allergenic or not, 
      specific for the allergen source or widely distributed (panallergens). New 
      technologies offer the opportunity for a more accurate component-resolved 
      diagnosis, of benefit especially to polysensitized allergic patients. The basic 
      elements of molecular diagnostics with potential relevance to immunotherapy 
      prescription are reviewed here, with a focus on Southern European sensitization 
      patterns to pollen allergens. We propose a basic algorithm regarding 
      component-resolved diagnostic work-up for pollen allergen-specific immunotherapy 
      candidates in Southern Europe; this and similar algorithms can form the basis of 
      improved patient management, conceptually a 'Component-Resolved Allergy 
      Management'.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Douladiris, Nikolaos
AU  - Douladiris N
AD  - Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
FAU - Savvatianos, Savvas
AU  - Savvatianos S
FAU - Roumpedaki, Irene
AU  - Roumpedaki I
FAU - Skevaki, Chrysanthi
AU  - Skevaki C
FAU - Mitsias, Dimitrios
AU  - Mitsias D
FAU - Papadopoulos, Nikolaos G
AU  - Papadopoulos NG
LA  - eng
PT  - Journal Article
DEP - 20130731
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Plant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Algorithms
MH  - Allergens/*administration & dosage/immunology
MH  - Antigens, Plant/administration & dosage/immunology
MH  - Desensitization, Immunologic/*methods
MH  - Europe
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Molecular Diagnostic Techniques/*methods
MH  - Plant Proteins/administration & dosage/immunology
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Seasonal/diagnosis/*therapy
EDAT- 2013/08/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/08/08 06:00
PHST- 2013/02/20 00:00 [received]
PHST- 2013/05/17 00:00 [accepted]
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 000353113 [pii]
AID - 10.1159/000353113 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2013;162(2):163-72. doi: 10.1159/000353113. Epub 2013 
      Jul 31.