PMID- 23924085
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1423-0127 (Electronic)
IS  - 1021-7770 (Print)
IS  - 1021-7770 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Aug 7
TI  - Brain-derived neurotrophic factor (Val66Met) polymorphism and olfactory ability 
      in young adults.
PG  - 57
LID - 10.1186/1423-0127-20-57 [doi]
AB  - BACKGROUND: Brain- derived neurotrophic factor (BDNF) is linked to 
      neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which 
      are often characterized by olfactory impairment. A specific single nucleotide 
      polymorphism of the BDNF gene, the Val66Met, modulates intracellular trafficking 
      and activity-dependent secretion of BDNF protein. The aim of this study was to 
      investigate a possible association between brain- derived neurotrophic factor 
      Val66Met polymorphism and olfactory function, a well-known biomarker for 
      neurodegeneration, in healthy young adults. A total of 101 subjects (45 males, 
      age 38.7 +/- 9.4 years) were assessed using the Sniffin' Sticks Extended Test, a 
      highly reliable commercial olfactory test composed of three sub-parts, 
      calculating olfactory threshold (sensitivity), odor discrimination and odor 
      identification. The Val66Met polymorphism was determined by polymerase chain 
      reaction -restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: 
      An impaired function in Met carriers was found, especially when compared to 
      subjects with Val/Val genotype, in the threshold (5.5 +/- 2.0 vs 6.5 +/- 1.8, 
      p = 0.009), discrimination (10.3+/- 2.5 vs 11.9 +/- 2.2, p = 0.002), and 
      identification task (13.3 +/- 1.6 vs 14.1 +/- 1.3, p = 0.007), as well as in the 
      overall TDI Score (29.1 +/- 4.5 vs 32.6 +/- 3.9, p < 0.001). CONCLUSIONS: These 
      findings appear to have implications for the evaluation of olfactory function and 
      the relation of its impairment to cognitive decline and neurodegenerative 
      disease.
FAU - Tonacci, Alessandro
AU  - Tonacci A
FAU - Borghini, Andrea
AU  - Borghini A
FAU - Mercuri, Antonella
AU  - Mercuri A
FAU - Pioggia, Giovanni
AU  - Pioggia G
FAU - Andreassi, Maria Grazia
AU  - Andreassi MG
LA  - eng
PT  - Journal Article
DEP - 20130807
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alzheimer Disease/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Olfactory Cortex/pathology
MH  - Parkinson Disease/*genetics/pathology
MH  - Polymorphism, Single Nucleotide
PMC - PMC3750534
EDAT- 2013/08/09 06:00
MHDA- 2015/03/31 06:00
PMCR- 2013/08/07
CRDT- 2013/08/09 06:00
PHST- 2013/06/11 00:00 [received]
PHST- 2013/08/01 00:00 [accepted]
PHST- 2013/08/09 06:00 [entrez]
PHST- 2013/08/09 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2013/08/07 00:00 [pmc-release]
AID - 1423-0127-20-57 [pii]
AID - 10.1186/1423-0127-20-57 [doi]
PST - epublish
SO  - J Biomed Sci. 2013 Aug 7;20(1):57. doi: 10.1186/1423-0127-20-57.