PMID- 23925357
OWN - NLM
STAT- MEDLINE
DCOM- 20150505
LR  - 20161125
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 52
IP  - 4
DP  - 2013 Apr
TI  - [An analysis of factors affecting the prognosis of patients with cardiac 
      amyloidosis].
PG  - 305-8
AB  - OBJECTIVE: To analyze the clinical characteristics, diagnosis, treatment and 
      outcome of patients with cardiac amyloidosis (CA). METHODS: Clinical data from 18 
      patients diagnosed as CA by endomyocardial biopsy (EMB) from 1995 to 2005 were 
      retrospectively analyzed. RESULTS: Among the 18 patients with CA, all patients 
      had reduced diastolic dysfunction; 12 had mitral valve early diastolic blood flow 
      peak velocity/late diastolic blood flow peak velocity (E/A) > 2.0 and ventricular 
      diastolic early filling deceleration time (DT) < 150 ms; 12 had left ventricular 
      ejection fraction (LVEF) < 50%; and 13 had New York Heart Association (NYHA) 
      classification III or IV. The 1-year, 3-year and 5-year survival rates of 18 
      patients with CA were 67%, 44% and 17%, respectively. Kaplan-Meier analysis 
      showed, NYHA functional class > II, E/A > 2.0 and DT < 150 ms were associated 
      with increased mortality (log-rank statistic P = 0.026 and 0.001, respectively). 
      CA patients with chemotherapy before heart failure were associated with decreased 
      mortality and extend survival. CONCLUSIONS: The mortality rate goes up and 
      survival rate gradually descends as prolonged onset time. NYHA functional class 
      >IIand E/A > 2.0 (DT< 150 ms) are associated with mortality.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Cardiology, General Hospital of PLA, Beijing 100853, China.
FAU - Ren, Yi-Hong
AU  - Ren YH
FAU - Qian, Geng
AU  - Qian G
FAU - Zhou, Chao-Fei
AU  - Zhou CF
FAU - Zhang, Qing-Kao
AU  - Zhang QK
FAU - Zhao, Peng-Cheng
AU  - Zhao PC
FAU - Liu, Guo-Shu
AU  - Liu GS
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Aged
MH  - Amyloidosis/mortality/*pathology
MH  - Biopsy
MH  - Cardiac Catheterization
MH  - Cardiomyopathies
MH  - Diastole/physiology
MH  - Echocardiography, Doppler
MH  - Heart Failure/diagnostic imaging/mortality/*physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Mitral Valve/diagnostic imaging/physiopathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*physiopathology
MH  - Ventricular Function, Left
EDAT- 2013/08/09 06:00
MHDA- 2015/05/06 06:00
CRDT- 2013/08/09 06:00
PHST- 2013/08/09 06:00 [entrez]
PHST- 2013/08/09 06:00 [pubmed]
PHST- 2015/05/06 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2013 Apr;52(4):305-8.