PMID- 23926279
OWN - NLM
STAT- MEDLINE
DCOM- 20140213
LR  - 20171114
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 85
IP  - 1
DP  - 2014 Jan
TI  - Posterior cingulate epilepsy: clinical and neurophysiological analysis.
PG  - 44-50
LID - 10.1136/jnnp-2013-305604 [doi]
AB  - OBJECTIVE: Posterior cingulate epilepsy (PCE) is misleading because the seizure 
      onset is located in an anatomically deep and semiologically silent area. This 
      type of epilepsy is rare and has not been well described yet. Knowledge of the 
      characteristics of PCE is important for the interpretation of presurgical 
      evaluation and better surgical strategy. The purpose of this study was to better 
      characterise the clinical and neurophysiological features of PCE. METHODS: This 
      retrospective analysis included seven intractable PCE patients. Six patients had 
      postcingulate ictal onset identified by stereotactic EEG (SEEG) evaluations. One 
      patient had a postcingulate tumour. We analysed clinical semiology, the scalp 
      EEG/SEEG findings and cortico-cortical evoked potential (CCEP). RESULTS: The 
      classifications of scalp EEG were various, including non-localisible, lateralised 
      to the seizure onset side, regional parieto-occipital, regional frontocentral and 
      regional temporal. Three of seven patients showed motor manifestations, including 
      bilateral asymmetric tonic seizures and hypermotor seizures. In these patients, 
      ictal activities spread to frontal (lateral premotor area, orbitofrontal cortex, 
      supplementary motor area, anteior cingulate gyrus) and parietal (precuneus, 
      posterior cingulate gyrus, inferior parietal lobule (IPL), postcentral gyrus) 
      areas. Four patients showed dialeptic seizures or automotor seizures, with 
      seizure spread to medial temporal or IPL areas. CCEP was performed in four 
      patients, suggesting electrophysiological connections from the posterior 
      cingulate gyrus to parietal, temporal, mesial occipital and mesial frontal areas. 
      CONCLUSIONS: This study revealed that the network from the posterior cingulate 
      gyrus and the semiology of PCE (motor manifestation vs dialeptic/automotor 
      seizure) varies depending upon the seizure spread patterns.
FAU - Enatsu, Rei
AU  - Enatsu R
AD  - Epilepsy Center, Cleveland Clinic Foundation, , Cleveland, Ohio, USA.
FAU - Bulacio, Juan
AU  - Bulacio J
FAU - Nair, Dileep R
AU  - Nair DR
FAU - Bingaman, William
AU  - Bingaman W
FAU - Najm, Imad
AU  - Najm I
FAU - Gonzalez-Martinez, Jorge
AU  - Gonzalez-Martinez J
LA  - eng
PT  - Journal Article
DEP - 20130807
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebrovascular Circulation
MH  - Electrodes, Implanted
MH  - Electroencephalography
MH  - Epilepsies, Partial/physiopathology/therapy
MH  - Epilepsy, Frontal Lobe/*physiopathology/*therapy
MH  - Evoked Potentials/physiology
MH  - Female
MH  - Gyrus Cinguli/physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography
MH  - Retrospective Studies
MH  - Seizures/physiopathology/therapy
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Wavelet Analysis
MH  - Young Adult
OTO - NOTNLM
OT  - Brain Mapping
OT  - Epilepsy
OT  - Neurophysiology
OT  - Neurosurgery
EDAT- 2013/08/09 06:00
MHDA- 2014/02/14 06:00
CRDT- 2013/08/09 06:00
PHST- 2013/08/09 06:00 [entrez]
PHST- 2013/08/09 06:00 [pubmed]
PHST- 2014/02/14 06:00 [medline]
AID - jnnp-2013-305604 [pii]
AID - 10.1136/jnnp-2013-305604 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2014 Jan;85(1):44-50. doi: 
      10.1136/jnnp-2013-305604. Epub 2013 Aug 7.