PMID- 23927822
OWN - NLM
STAT- MEDLINE
DCOM- 20151001
LR  - 20150124
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 48
IP  - 1
DP  - 2015 Feb
TI  - Clinical manifestations of Kawasaki disease shock syndrome: a case-control study.
PG  - 43-50
LID - S1684-1182(13)00109-6 [pii]
LID - 10.1016/j.jmii.2013.06.005 [doi]
AB  - BACKGROUND: Kawasaki disease shock syndrome (KDSS) is a severe condition related 
      to Kawasaki disease (KD), and sometimes it is difficult to diagnose. This is a 
      case-control study to ascertain the clinical presentations, risk factors, and 
      clinical outcomes of children who had KDSS. MATERIALS AND METHODS: Children who 
      were hospitalized during 2001-2011 with the diagnosis of KD combined with 
      hypotension, sepsis, or shock were retrospectively reviewed and were defined as 
      case patients. For each case patient, three season-matched patients diagnosed as 
      having KD with normal blood pressure were identified to serve as control 
      patients. Demographic characteristics, clinical presentations, laboratory 
      features, therapies, and outcomes were analyzed. RESULTS: Nine KDSS patients and 
      27 control patients were identified. The average age of patients with KDSS was 
      3.2 +/- 3.2 years. Compared with controls, KDSS patients were less likely to have a 
      diagnosis of KD at admission (22.2% vs. 66.7%) and had a higher risk of coronary 
      artery dilatation (77.8% vs. 11.1%). Risk factors for KDSS included higher 
      neutrophil counts and proportions of bands, higher C-reactive protein (CRP), and 
      lower platelet counts. All case patients received aspirin therapy; eight patients 
      received intravenous immunoglobulin therapy, with two receiving more than one 
      course. Seven KDSS patients required fluid resuscitation, and eight patients 
      required vasoactive infusions. CONCLUSION: Patients with KDSS may have uneven 
      clinical course and may be misdiagnosed in the beginning. They may have more 
      prominent inflammatory markers in the early phase and higher risk of coronary 
      artery dilatation.
CI  - Copyright (c) 2013. Published by Elsevier B.V.
FAU - Chen, Pei-Shin
AU  - Chen PS
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Chi, Hsin
AU  - Chi H
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Mackay 
      Medicine, Nursing and Management College, Taipei, Taiwan; Graduate Institute of 
      Clinical Medicine, National Taiwan University College of Medicine, Taipei, 
      Taiwan.
FAU - Huang, Fu-Yuan
AU  - Huang FY
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Peng, Chun-Chih
AU  - Peng CC
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Mackay 
      Medicine, Nursing and Management College, Taipei, Taiwan.
FAU - Chen, Ming-Ren
AU  - Chen MR
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Mackay 
      Medicine, Nursing and Management College, Taipei, Taiwan.
FAU - Chiu, Nan-Chang
AU  - Chiu NC
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Mackay 
      Medicine, Nursing and Management College, Taipei, Taiwan. Electronic address: 
      ncc88@ms2.mmh.org.tw.
LA  - eng
PT  - Journal Article
DEP - 20130806
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hypotension/pathology
MH  - Infant
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*complications/*pathology
MH  - Risk Factors
MH  - Sepsis/pathology
MH  - Shock/*pathology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Children
OT  - Kawasaki disease
OT  - Kawasaki disease shock syndrome
OT  - Risk factors
EDAT- 2013/08/10 06:00
MHDA- 2015/10/02 06:00
CRDT- 2013/08/10 06:00
PHST- 2012/12/06 00:00 [received]
PHST- 2013/05/15 00:00 [revised]
PHST- 2013/06/24 00:00 [accepted]
PHST- 2013/08/10 06:00 [entrez]
PHST- 2013/08/10 06:00 [pubmed]
PHST- 2015/10/02 06:00 [medline]
AID - S1684-1182(13)00109-6 [pii]
AID - 10.1016/j.jmii.2013.06.005 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2015 Feb;48(1):43-50. doi: 
      10.1016/j.jmii.2013.06.005. Epub 2013 Aug 6.