PMID- 23928567
OWN - NLM
STAT- MEDLINE
DCOM- 20150818
LR  - 20141216
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Linking)
VI  - 22
IP  - 1
DP  - 2015 Jan
TI  - Efficacy of exercise training in symptomatic patients with hypertrophic 
      cardiomyopathy: results of a structured exercise training program in a cardiac 
      rehabilitation center.
PG  - 13-9
LID - 10.1177/2047487313501277 [doi]
AB  - BACKGROUND: Recent data suggest that exercise training (ET) confers significant 
      symptomatic and functional improvements in patients with diastolic dysfunction, 
      and thus may be beneficial in patients with hypertrophic cardiomyopathy (HCM). 
      However, there are no data regarding the safety or efficacy of ET in HCM 
      patients. DESIGN: A prospective non-randomized intervention design was used. 
      METHODS: We enrolled 20 patients with symptomatic HCM, significantly limited in 
      everyday activity, into a supervised cardiac rehabilitation exercise program. 
      RESULTS: Patients were 62 +/- 13 years old, in New York Heart Association (NYHA) 
      functional class II (35%) or III (65%), had a mean interventricular septum 
      dimension of 17 +/- 5 mm and left ventricular ejection fraction (LVEF) of 53 +/- 15%. 
      Left ventricular outflow gradient was present at rest in nine patients (mean 51 +/- 
      24 mm Hg) and six patients had an implantable defibrillator. Exercise 
      prescription was based on heart rate reserve (HRR) determined from a 
      symptom-limited graded exercise stress test. Exercise intensity was gradually 
      increased from 50% to 85% of the HRR over the training period. Patients completed 
      an average of 41 +/- 8 hours of aerobic ET. No adverse events or sustained 
      ventricular arrhythmias occurred during the training program. Functional 
      capacity, assessed by a graded exercise test, improved from 4.7 +/- 2.2 to 7.2 +/- 
      2.8 metabolic equivalents (METs) (p = 0.01). NYHA functional class improved from 
      baseline by >/= 1 grade in 10 patients (50%) and none experiencing deterioration 
      during follow-up. CONCLUSIONS: The present study suggests that patients with HCM 
      who remain symptomatic despite medical therapy may achieve considerable 
      functional improvement through a supervised ET program.
CI  - (c) The European Society of Cardiology 2013 Reprints and permissions: 
      sagepub.co.uk/journalsPermissions.nav.
FAU - Klempfner, Robert
AU  - Klempfner R
AD  - Cardiac Rehabilitation Institute, Sheba Medical Center, Israel 
      klempfner@gmail.com.
FAU - Kamerman, Tamir
AU  - Kamerman T
AD  - Cardiac Rehabilitation Institute, Sheba Medical Center, Israel.
FAU - Schwammenthal, Ehud
AU  - Schwammenthal E
AD  - Cardiac Rehabilitation Institute, Sheba Medical Center, Israel Sackler Faculty of 
      Medicine, Tel Aviv University, Israel.
FAU - Nahshon, Amira
AU  - Nahshon A
AD  - Cardiac Rehabilitation Institute, Sheba Medical Center, Israel.
FAU - Hay, Ilan
AU  - Hay I
AD  - Cardiac Rehabilitation Institute, Sheba Medical Center, Israel.
FAU - Goldenberg, Ilan
AU  - Goldenberg I
AD  - Cardiac Rehabilitation Institute, Sheba Medical Center, Israel Sackler Faculty of 
      Medicine, Tel Aviv University, Israel.
FAU - Dov, Freimark
AU  - Dov F
AD  - Sackler Faculty of Medicine, Tel Aviv University, Israel Heart Failure Service, 
      Sheba Medical Center, Israel.
FAU - Arad, Michael
AU  - Arad M
AD  - Sackler Faculty of Medicine, Tel Aviv University, Israel Heart Failure Service, 
      Sheba Medical Center, Israel.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20130808
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
SB  - IM
CIN - Eur J Prev Cardiol. 2015 Mar;22(3):354-5. PMID: 24445264
MH  - Aged
MH  - Cardiomyopathy, 
      Hypertrophic/complications/diagnosis/physiopathology/*rehabilitation
MH  - Exercise Test
MH  - *Exercise Therapy
MH  - Exercise Tolerance
MH  - Feasibility Studies
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Recovery of Function
MH  - *Rehabilitation Centers
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnosis/etiology/physiopathology/*rehabilitation
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Exercise training
OT  - cardiac rehabilitation
OT  - heart failure
OT  - hypertrophic cardiomyopathy
EDAT- 2013/08/10 06:00
MHDA- 2015/08/19 06:00
CRDT- 2013/08/10 06:00
PHST- 2013/08/10 06:00 [entrez]
PHST- 2013/08/10 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - 2047487313501277 [pii]
AID - 10.1177/2047487313501277 [doi]
PST - ppublish
SO  - Eur J Prev Cardiol. 2015 Jan;22(1):13-9. doi: 10.1177/2047487313501277. Epub 2013 
      Aug 8.