PMID- 23928832
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20141120
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 33
IP  - 3
DP  - 2014 Mar
TI  - The effect of lead exposure on tracheal responsiveness to methacholine and 
      ovalbumin, total and differential white blood cells count, and serum levels of 
      immunoglobulin E, histamine, and cytokines in guinea pigs.
PG  - 325-33
LID - 10.1177/0960327113499040 [doi]
AB  - The effect of exposure to inhaled lead acetate in guinea pigs was evaluated. The 
      present study comprised of five groups of guinea pigs including control (C), 
      sensitized to ovalbumin (OA; S) and three groups exposed to 0.1, 0.2, and 0.4 M 
      inhaled lead (Pb; n = 6 for each group). Tracheal responsiveness to methacholine 
      and OA, total and differential white blood cells (WBCs) count in lung lavage, 
      serum levels of cytokines (interferon gamma (IFN-gamma) and interleukin 4 (IL-4)), 
      histamines, and immunoglobulin E (IgE), and Pb concentration in lung were 
      measured. Tracheal responsiveness to methacholine, OA, total and differential WBC 
      types as well as IL-4, IFN-gamma, histamine, and IgE were significantly increased but 
      IFN-gamma/IL-4 were significantly decreased in sensitized animals as well as those 
      exposed to high Pb concentrations when compared with the control group (from p < 
      0.05 to p < 0.001). In addition, there was not a significant difference in most 
      measured values between animals exposed to high Pb concentration and group S. The 
      Pb concentration in lung tissues of animals exposed to all three Pb 
      concentrations was significantly higher than that of group C (p < 0.001 for all 
      cases).These results showed that inhaled lead acetate exposure can induce lung 
      inflammatory changes similar to sensitized animals. Therefore, exposure to 
      environmental Pb pollution may cause asthma-like changes.
FAU - Farkhondeh, T
AU  - Farkhondeh T
AD  - 1Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, 
      Tehran, Islamic Republic of Iran.
FAU - Boskabady, M H
AU  - Boskabady MH
FAU - Jalali, S
AU  - Jalali S
FAU - Bayrami, G
AU  - Bayrami G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130808
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Cytokines)
RN  - 0 (Serine Proteinase Inhibitors)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 207137-56-2 (Interleukin-4)
RN  - 2P299V784P (Lead)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Blood Cell Count
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Bronchodilator Agents/*pharmacology
MH  - Cytokines/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Guinea Pigs
MH  - Histamine/*metabolism
MH  - Immunoglobulin E/*metabolism
MH  - In Vitro Techniques
MH  - Interferon-gamma/metabolism
MH  - Interleukin-4/metabolism
MH  - Lead/metabolism/*toxicity
MH  - Lead Poisoning/*pathology
MH  - Leukocyte Count
MH  - Leukocytes/*drug effects
MH  - Male
MH  - Methacholine Chloride/*pharmacology
MH  - Muscle Contraction/drug effects
MH  - Ovalbumin/*pharmacology
MH  - Serine Proteinase Inhibitors/*pharmacology
MH  - Trachea/*drug effects/metabolism/*physiopathology
OTO - NOTNLM
OT  - Lead acetate
OT  - asthma
OT  - inflammation
OT  - sensitized animals
OT  - tracheal responsiveness
EDAT- 2013/08/10 06:00
MHDA- 2014/10/01 06:00
CRDT- 2013/08/10 06:00
PHST- 2013/08/10 06:00 [entrez]
PHST- 2013/08/10 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - 0960327113499040 [pii]
AID - 10.1177/0960327113499040 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2014 Mar;33(3):325-33. doi: 10.1177/0960327113499040. Epub 2013 
      Aug 8.