PMID- 23930499
OWN - NLM
STAT- MEDLINE
DCOM- 20140710
LR  - 20130812
IS  - 1004-5619 (Print)
IS  - 1004-5619 (Linking)
VI  - 29
IP  - 2
DP  - 2013 Apr
TI  - [Relation between expression of cerebral beta-APP in the chronic alcoholism rats 
      and death caused by TSAH].
PG  - 91-5
AB  - OBJECTIVE: By observing the cerebral beta-amyloid precursor protein (beta-APP) 
      expression in the chronic alcoholism rats with slight cerebral injury, to discuss 
      the correlation of chronic alcoholism and death caused by traumatic subarachnoid 
      haemorrhage (TSAH). METHODS: Sixty male SD rats were randomly divided into 
      watering group, watering group with strike, alcoholism group and alcoholism group 
      with strike. Among them, the alcohol was used for continuous 4 weeks in 
      alcoholism groups and the concussion was made in groups with strike. In each 
      group, HE staining and immunohistochemical staining of the cerebral tissues were 
      done and the results were analyzed by the histopathologic image system. RESULTS: 
      In watering group, there was no abnormal. In watering group with strike, mild 
      neuronic congestion was found. In alcoholism group, vascular texture on cerebral 
      surface was found. And the neurons arranged in disorder with dilated 
      intercellular space. In alcoholism group with strike, diffuse congestion on 
      cerebral surface was found. And there was TSAH with thick-layer patches around 
      brainstem following irregular axonotmesis. The quantity of beta-APP IOD in 
      alcoholism group was significantly higher in the frontal lobe, hippocampus, 
      cerebellum, brainstem than those in watering group with strike and alcoholism 
      group with strike. CONCLUSION: The cerebral tissues with chronic alcoholism, due 
      to the decreasing tolerance, could cause fatal TSAH and pathological changes in 
      cerebral tissues of rats under slight cerebral injury.
FAU - Wei, Lai
AU  - Wei L
AD  - Department of Forensic Medicine, Hubei University of Medicine, Shiyan 442000, 
      China. weilai1226@126.com
FAU - Lei, Huai-Cheng
AU  - Lei HC
FAU - Yu, Xiao-Jun
AU  - Yu XJ
FAU - Lai, Xiao-Ping
AU  - Lai XP
FAU - Qian, Hong
AU  - Qian H
FAU - Xu, Xiao-Hu
AU  - Xu XH
FAU - Zhu, Fang-Cheng
AU  - Zhu FC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Fa Yi Xue Za Zhi
JT  - Fa yi xue za zhi
JID - 9426151
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcoholism/*complications/metabolism/pathology
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Animals
MH  - Brain/*metabolism/pathology
MH  - Brain Concussion/*complications/metabolism/pathology
MH  - Disease Models, Animal
MH  - Ethanol/adverse effects
MH  - Male
MH  - Neurons/metabolism/pathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Subarachnoid Hemorrhage, Traumatic/*etiology/mortality/pathology
EDAT- 2013/08/13 06:00
MHDA- 2014/07/11 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/07/11 06:00 [medline]
PST - ppublish
SO  - Fa Yi Xue Za Zhi. 2013 Apr;29(2):91-5.