PMID- 23930598
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20131105
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 38
IP  - 9
DP  - 2013 Nov
TI  - Brain-derived neurotrophic factor interacts with astrocytes and neurons to 
      control respiration.
PG  - 3261-9
LID - 10.1111/ejn.12320 [doi]
AB  - Respiratory rhythm is generated and modulated in the brainstem. Neuronal 
      involvement in respiratory control and rhythmogenesis is now clearly established. 
      However, glial cells have also been shown to modulate the activity of brainstem 
      respiratory groups. Although the potential involvement of other glial cell 
      type(s) cannot be excluded, astrocytes are clearly involved in this modulation. 
      In parallel, brain-derived neurotrophic factor (BDNF) also modulates respiratory 
      rhythm. The currently available data on the respective roles of astrocytes and 
      BDNF in respiratory control and rhythmogenesis lead us to hypothesize that there 
      is BDNF-mediated control of the communication between neurons and astrocytes in 
      the maintenance of a proper neuronal network capable of generating a stable 
      respiratory rhythm. According to this hypothesis, progression of Rett syndrome, 
      an autism spectrum disease with disordered breathing, can be stabilized in mouse 
      models by re-expressing the normal gene pattern in astrocytes or microglia, as 
      well as by stimulating the BDNF signaling pathway. These results illustrate how 
      the signaling mechanisms by which glia exerts its effects in brainstem 
      respiratory groups is of great interest for pathologies associated with 
      neurological respiratory disorders.
CI  - (c) 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Caravagna, Celine
AU  - Caravagna C
AD  - Department of Pediatrics, Laval University, Centre de Recherche du Centre 
      Hospitalier Universitaire (CHU) de Quebec, Hopital St-Francois d'Assise, 10 Rue 
      de l'Espinay, Room D0-742, Quebec, QC, Canada.
FAU - Soliz, Jorge
AU  - Soliz J
FAU - Seaborn, Tommy
AU  - Seaborn T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130811
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism/physiology
MH  - Brain Stem/metabolism/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Neurons/*metabolism/physiology
MH  - *Respiration
MH  - Rett Syndrome/metabolism/physiopathology
OTO - NOTNLM
OT  - TrkB
OT  - astrocyte
OT  - brain-derived neurotrophic factor
OT  - brainstem
OT  - rhythmogenesis
EDAT- 2013/08/13 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/05/27 00:00 [received]
PHST- 2013/06/24 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - 10.1111/ejn.12320 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2013 Nov;38(9):3261-9. doi: 10.1111/ejn.12320. Epub 2013 Aug 11.