PMID- 23930698
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20131105
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 38
IP  - 9
DP  - 2013 Nov
TI  - Maximized song learning of juvenile male zebra finches following BDNF expression 
      in the HVC.
PG  - 3338-44
LID - 10.1111/ejn.12329 [doi]
AB  - During song learning, vocal patterns are matched to an auditory memory acquired 
      from a tutor, a process involving sensorimotor feedback. Song sensorimotor 
      learning and song production of birds is controlled by a set of interconnected 
      brain nuclei, the song control system. In male zebra finches, the beginning of 
      the sensorimotor phase of song learning parallels an increase of the 
      brain-derived neurotrophic factor (BDNF) in just one part of the song control 
      system, the forebrain nucleus HVC. We report here that transient BDNF-mRNA 
      upregulation in the HVC results in a maximized copying of song syllables. Each 
      treated bird shows motor learning to an extent similar to that of the selected 
      best learners among untreated zebra finches. Because this result was not found 
      following BDNF overexpression in the target areas of HVC within the song system, 
      HVC-anchored mechanisms are limiting sensorimotor vocal learning.
CI  - (c) 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Dittrich, Falk
AU  - Dittrich F
AD  - Department of Behavioural Neurobiology, Max Planck Institute for Ornithology, 
      82319, Seewiesen, Germany; Department of Developmental and Behavioral 
      Neurobiology, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.
FAU - Ter Maat, Andries
AU  - Ter Maat A
FAU - Jansen, Rene F
AU  - Jansen RF
FAU - Pieneman, Anton
AU  - Pieneman A
FAU - Hertel, Moritz
AU  - Hertel M
FAU - Frankl-Vilches, Carolina
AU  - Frankl-Vilches C
FAU - Gahr, Manfred
AU  - Gahr M
LA  - eng
PT  - Journal Article
DEP - 20130811
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Finches
MH  - *Learning
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
MH  - Somatosensory Cortex/metabolism/*physiology
MH  - Up-Regulation
MH  - *Vocalization, Animal
OTO - NOTNLM
OT  - social environment
OT  - song control system
OT  - songbirds
EDAT- 2013/08/13 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/01/01 00:00 [received]
PHST- 2013/06/28 00:00 [revised]
PHST- 2013/07/02 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - 10.1111/ejn.12329 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2013 Nov;38(9):3338-44. doi: 10.1111/ejn.12329. Epub 2013 Aug 11.