PMID- 23930843
OWN - NLM
STAT- MEDLINE
DCOM- 20140321
LR  - 20140117
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 111
IP  - 2
DP  - 2014 Jan 28
TI  - Fruit juice drinks prevent endogenous antioxidant response to high-fat meal 
      ingestion.
PG  - 294-300
LID - 10.1017/S0007114513002407 [doi]
AB  - High-fat meals (HFM) induce metabolic stress, leading to the activation of 
      protective mechanisms, including inflammation and endogenous antioxidant 
      defences. In the present study, we investigated the effects of antioxidant-rich 
      fruit juice drinks on the endogenous antioxidant response induced by HFM. In a 
      double-blind, cross-over design (10 d washout), fourteen overweight volunteers 
      were randomly assigned to one of the following interventions: HFM+500 ml placebo 
      beverage (HFM-PB, free from fruit); HFM+500 ml antioxidant beverage 1 (HFM-AB1; 
      apple, grape, blueberry and pomegranate juices and grape skin, grape seed and 
      green tea extracts); HFM+500 ml antioxidant beverage 2 (HFM-AB2; pineapple, black 
      currant and plum juices). HFM-PB consumption increased the plasma levels of 
      thiols (SH) (4 h, P< 0.001) and uric acid (UA) (2 h, P< 0.01) and total 
      radical-trapping antioxidant parameter (TRAP) (4 h, P< 0.01). Following the 
      consumption of drinks, UA production was significantly reduced with respect to 
      placebo beverage consumption 8 h after HFM-AB2 consumption (P< 0.05). SH levels 
      were reduced 0.5 (P< 0.05), 1 (P< 0.05) and 2 h (P< 0.01) after HFM-AB1 
      consumption and 2, 4 and 8 h (P< 0.05) after HFM-AB2 consumption. Plasma TRAP 
      (2 h, P< 0.001) and urinary ferric reducing antioxidant power (0-8 h, P< 0.01) 
      were increased by HFM-AB1 consumption, the drink with the highest in vitro 
      antioxidant capacity, but not by HFM-AB2 consumption. In urine, UA levels were 
      significantly increased from basal levels after the consumption of HFM-PB and 
      HFM-AB2. However, neither of the beverages increased the urinary excretion of UA 
      with respect to the placebo beverage. In conclusion, the increase in UA and SH 
      levels induced by HFM as part of an endogenous antioxidant response to 
      postprandial stress can be prevented by the concomitant ingestion of 
      antioxidant-rich fruit juice drinks.
FAU - Miglio, Cristiana
AU  - Miglio C
AD  - Agricultural Research Council (CRA), Via Ardeatina 546, 00178 Rome, Italy.
FAU - Peluso, Ilaria
AU  - Peluso I
AD  - Agricultural Research Council (CRA), Via Ardeatina 546, 00178 Rome, Italy.
FAU - Raguzzini, Anna
AU  - Raguzzini A
AD  - Agricultural Research Council (CRA), Via Ardeatina 546, 00178 Rome, Italy.
FAU - Villano, Deborah V
AU  - Villano DV
AD  - Food and Nutrition Unit, IRCCS San Raffaele Pisana, Via della Pisana 235, 00163 
      Rome, Italy.
FAU - Cesqui, Eleonora
AU  - Cesqui E
AD  - Agricultural Research Council (CRA), Via Ardeatina 546, 00178 Rome, Italy.
FAU - Catasta, Giovina
AU  - Catasta G
AD  - Agricultural Research Council (CRA), Via Ardeatina 546, 00178 Rome, Italy.
FAU - Toti, Elisabetta
AU  - Toti E
AD  - Agricultural Research Council (CRA), Via Ardeatina 546, 00178 Rome, Italy.
FAU - Serafini, Mauro
AU  - Serafini M
AD  - Agricultural Research Council (CRA), Via Ardeatina 546, 00178 Rome, Italy.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130812
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Antioxidants)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Adult
MH  - Antioxidants/*metabolism
MH  - Beverages/*analysis
MH  - Cross-Over Studies
MH  - *Dietary Fats
MH  - Double-Blind Method
MH  - *Fruit
MH  - Humans
MH  - Middle Aged
MH  - Overweight
EDAT- 2013/08/13 06:00
MHDA- 2014/03/22 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - S0007114513002407 [pii]
AID - 10.1017/S0007114513002407 [doi]
PST - ppublish
SO  - Br J Nutr. 2014 Jan 28;111(2):294-300. doi: 10.1017/S0007114513002407. Epub 2013 
      Aug 12.