PMID- 23930970
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20240318
IS  - 1945-0257 (Electronic)
IS  - 1945-0265 (Print)
IS  - 1945-0257 (Linking)
VI  - 17
IP  - 10
DP  - 2013 Oct
TI  - Association of -2518A>G promoter polymorphism in the monocyte chemoattractant 
      protein-1 (MCP-1) gene with type 2 diabetes and coronary artery disease.
PG  - 750-5
LID - 10.1089/gtmb.2013.0227 [doi]
AB  - AIMS: Inflammatory markers play an important role in the development of diseases 
      related to metabolic syndrome, such as type 2 diabetes (T2D) and coronary artery 
      disease (CAD). The present study evaluates the association of -2518A>G 
      polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with T2D and 
      CAD. RESULTS: The frequency of the G allele is greater in CAD cases (35%) as 
      compared to T2D (24.6%) and controls (31%), while the frequency of the A allele 
      is higher in T2D cases (75.4%) as compared to CAD cases (65%) and controls (69%). 
      The analysis has revealed that in comparison to T2D cases, the G allele increases 
      the risk of CAD by 1.9-fold (p=0.008; odds ratio [OR]=1.9, 1.18-3.06 at 95% 
      confidence interval [CI]) but in comparison to controls the G-allele provided 
      protection against T2D (p=0.011; OR=0.55, 0.35-0.87 at 95% CI), both under the 
      dominant model (AG+GG vs. AA). CONCLUSION: Results of the present study suggests 
      that G-allele of MCP-1 -2518A>G polymorphism is associated with reduced risk of 
      T2D and increased risk of CAD in the population of Punjab. The results indicate 
      that there is a difference in the association of risk alleles with phenotypes of 
      metabolic syndrome. Body mass index and waist circumference are important risk 
      factors for T2D in the population of Punjab.
FAU - Kaur, Ramandeep
AU  - Kaur R
AD  - 1 Department of Human Genetics, Guru Nanak Dev University , Amritsar, Punjab, 
      India .
FAU - Matharoo, Kawaljit
AU  - Matharoo K
FAU - Arora, Punit
AU  - Arora P
FAU - Bhanwer, A J S
AU  - Bhanwer AJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130809
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - *Alleles
MH  - Chemokine CCL2/*genetics
MH  - Coronary Artery Disease/epidemiology/*genetics
MH  - Diabetes Complications/epidemiology/*genetics
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - *Gene Frequency
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
PMC - PMC3780327
EDAT- 2013/08/13 06:00
MHDA- 2014/04/20 06:00
PMCR- 2014/10/01
CRDT- 2013/08/13 06:00
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - 10.1089/gtmb.2013.0227 [pii]
AID - 10.1089/gtmb.2013.0227 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2013 Oct;17(10):750-5. doi: 10.1089/gtmb.2013.0227. 
      Epub 2013 Aug 9.