PMID- 23932027
OWN - NLM
STAT- MEDLINE
DCOM- 20140218
LR  - 20130820
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1307
DP  - 2013 Sep 13
TI  - Dispersive micro solid-phase extraction for the rapid analysis of synthetic 
      polycyclic musks using thermal desorption gas chromatography-mass spectrometry.
PG  - 34-40
LID - S0021-9673(13)01134-5 [pii]
LID - 10.1016/j.chroma.2013.07.074 [doi]
AB  - A simple and solvent-free method for the rapid analysis of five synthetic 
      polycyclic musks in water samples is described. The method involves the use of 
      dispersive micro solid-phase extraction (D-mu-SPE) coupled with direct thermal 
      desorption (TD) gas chromatography-mass spectrometry (GC-MS) operating in the 
      selected-ion-storage (SIS) mode. The parameters affecting the extraction 
      efficiency of the target analytes from water sample and the thermal desorption 
      conditions in the GC injection-port were optimized using a central composite 
      design method. The optimal extraction conditions involved immersing 3.2mg of a 
      typical octadecyl (C18) bonded silica adsorbent (i.e., ENVI-18) in a 10mL water 
      sample. After extraction by vigorously shaking for 1.0min, the adsorbents were 
      collected and dried on a filter. The adsorbents were transferred to a micro-vial, 
      which was directly inserted into GC temperature-programmed injector, and the 
      extracted target analytes were then thermally desorbed in the GC injection-port 
      at 337 degrees C for 3.8min. The limits of quantitation (LOQs) were determined to be 
      1.2-3.0ng/L. Precision, as indicated by relative standard deviations (RSDs), was 
      less than 9% for both intra- and inter-day analysis. Accuracy, expressed as the 
      mean extraction recovery, was between 74 and 90%. A preliminary analysis of the 
      river water samples revealed that galaxolide (HHCB) and tonalide (AHTN) were the 
      two most common synthetic polycyclic musks present. Using a standard addition 
      method, their concentrations were determined to in the range from 11 to 140ng/L.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Chung, Wu-Hsun
AU  - Chung WH
AD  - Department of Chemistry, National Central University, Chung-Li 320, Taiwan; 
      Department of Chemical Engineering, Army Academy ROC, Chung-Li 320, Taiwan.
FAU - Tzing, Shin-Hwa
AU  - Tzing SH
FAU - Ding, Wang-Hsien
AU  - Ding WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130724
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Polycyclic Compounds)
RN  - 0 (Water Pollutants, Chemical)
RN  - 095I377U8F (musk)
SB  - IM
MH  - Analysis of Variance
MH  - Fatty Acids, Monounsaturated/*analysis/isolation & purification
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Limit of Detection
MH  - Linear Models
MH  - Polycyclic Compounds/*analysis/isolation & purification
MH  - Reproducibility of Results
MH  - Rivers/chemistry
MH  - Solid Phase Microextraction/*methods
MH  - Water Pollutants, Chemical/analysis/isolation & purification
OTO - NOTNLM
OT  - Dispersive micro solid-phase extraction
OT  - Synthetic musks
OT  - Thermal desorption-GC-MS
OT  - Water analysis
EDAT- 2013/08/13 06:00
MHDA- 2014/02/19 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/03/17 00:00 [received]
PHST- 2013/07/18 00:00 [revised]
PHST- 2013/07/18 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/02/19 06:00 [medline]
AID - S0021-9673(13)01134-5 [pii]
AID - 10.1016/j.chroma.2013.07.074 [doi]
PST - ppublish
SO  - J Chromatogr A. 2013 Sep 13;1307:34-40. doi: 10.1016/j.chroma.2013.07.074. Epub 
      2013 Jul 24.