PMID- 23932722
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20200205
IS  - 1778-7254 (Electronic)
IS  - 1297-319X (Linking)
VI  - 81
IP  - 3
DP  - 2014 May
TI  - Risk of herpes/herpes zoster during anti-tumor necrosis factor therapy in 
      patients with rheumatoid arthritis. Systematic review and meta-analysis.
PG  - 215-21
LID - S1297-319X(13)00194-2 [pii]
LID - 10.1016/j.jbspin.2013.07.009 [doi]
AB  - BACKGROUND: TNF blockers have demonstrated efficacy in inflammatory rheumatic 
      diseases (IRDs). The drugs are associated with a moderate but definite risk of 
      bacterial infection, but risk of viral infection is not clearly known. OBJECTIVE: 
      To assess the risk of herpes zoster (HZ) reactivation in patients with rheumatoid 
      arthritis (RA) receiving TNF blockers as compared with DMARDs. METHODS: A 
      systematic search of literature up to March 2013 was performed, in MEDLINE, 
      EMBASE, the Cochrane library and abstracts from the ACR and EULAR congresses from 
      2008 to 2011. Studies were included if they reported the incidence of HZ, 
      respectively, in patients receiving anti-TNF and conventional DMARDs. RESULTS: 
      The literature search identified 3446 articles and 88 congress abstracts; a 
      manual search retrieved seven articles. Finally, 26 articles and nine abstracts 
      were included; six articles and one abstract were of meta-analyses estimating the 
      relative risk of HZ in patients with RA with a total follow-up of 163,077 
      patient-years. From the meta-analyses of data for seven registries, the pooled 
      risk ratio for HZ with TNF blockers was 1.61 [95% CI 1.16-2.23] (P = 0.004). 
      Proportions of severe HZ ranged from 4.9% to 20.9% with TNF-blockers and from 
      2.0% to 5.5% with conventional DMARDs, in the different registries. CONCLUSIONS: 
      This meta-analysis revealed a significantly increased risk of HZ, up to 61%, in 
      patients with IRD receiving TNF blockers. These data raise the issue of 
      systematic prophylactic treatment with known history of HZ or vaccination without 
      this history.
CI  - Copyright (c) 2013 Societe francaise de rhumatologie. Published by Elsevier SAS. 
      All rights reserved.
FAU - Che, Helene
AU  - Che H
AD  - Department of Rheumatology, Lapeyronie Hospital, University of Montpellier 1, 
      371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France. Electronic 
      address: che.helene@yahoo.fr.
FAU - Lukas, Cedric
AU  - Lukas C
AD  - Department of Rheumatology, Lapeyronie Hospital, University of Montpellier 1, 
      371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
FAU - Morel, Jacques
AU  - Morel J
AD  - Department of Rheumatology, Lapeyronie Hospital, University of Montpellier 1, 
      371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
FAU - Combe, Bernard
AU  - Combe B
AD  - Department of Rheumatology, Lapeyronie Hospital, University of Montpellier 1, 
      371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20130807
PL  - France
TA  - Joint Bone Spine
JT  - Joint bone spine
JID - 100938016
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - Joint Bone Spine. 2014 Jul;81(4):378-9. PMID: 24962976
CIN - Joint Bone Spine. 2014 Jul;81(4):379-80. PMID: 24962980
MH  - Antirheumatic Agents/*adverse effects
MH  - Arthritis, Rheumatoid/*drug therapy
MH  - Herpes Zoster/etiology
MH  - Herpesviridae Infections/*etiology
MH  - Humans
MH  - Risk
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
OTO - NOTNLM
OT  - Herpes zoster
OT  - Meta-analysis
OT  - Rheumatoid arthritis
OT  - TNF inhibitors
EDAT- 2013/08/13 06:00
MHDA- 2014/10/21 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/04/22 00:00 [received]
PHST- 2013/07/10 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - S1297-319X(13)00194-2 [pii]
AID - 10.1016/j.jbspin.2013.07.009 [doi]
PST - ppublish
SO  - Joint Bone Spine. 2014 May;81(3):215-21. doi: 10.1016/j.jbspin.2013.07.009. Epub 
      2013 Aug 7.