PMID- 23933156
OWN - NLM
STAT- MEDLINE
DCOM- 20140131
LR  - 20211021
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 555
DP  - 2013 Oct 25
TI  - Independent of 5-HT1A receptors, neurons in the paraventricular hypothalamus 
      mediate ACTH responses from MDMA.
PG  - 42-6
LID - S0304-3940(13)00715-5 [pii]
LID - 10.1016/j.neulet.2013.07.053 [doi]
AB  - Acute and chronic complications from the substituted amphetamine 
      3,4-methylenedioxymethamphetamine (MDMA) are linked to activation of the 
      hypothalamic-pituitary-adrenal (HPA) axis. How MDMA activates the HPA axis is not 
      known. HPA responses to stress are known to be mediated through the 
      paraventricular (PVH) hypothalamus and to involve serotonin-1a (5-HT1A) 
      receptors. We sought to determine if the PVH and 5-HT1A receptors were also 
      involved in mediating HPA responses to MDMA. Rats were pretreated with either 
      saline or a 5-HT1A antagonist, WAY-100635 (WAY), followed by a systemic dose of 
      MDMA (7.5mg/kg i.v.). Animals pretreated with WAY had significantly lower plasma 
      ACTH concentrations after MDMA. To determine if neurons in the PVH were involved, 
      and if their involvement was mediated by 5-HT1A receptors, rats implanted with 
      guide cannulas targeting the PVH were microinjected with the GABAA receptor 
      agonist muscimol, aCSF, or WAY followed by MDMA. Compared to aCSF, 
      microinjections of muscimol significantly attenuated the MDMA-induced rise in 
      plasma ACTH (126 vs. 588pg/ml, P=<0.01). WAY had no effect. Our data demonstrates 
      that neurons in the PVH, independent of 5-HT1A receptors, mediate ACTH responses 
      to MDMA.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Zaretsky, Dmitry V
AU  - Zaretsky DV
AD  - Department of Emergency Medicine, Indiana University School of Medicine, 
      Indianapolis, IN 46202, United States.
FAU - Zaretskaia, Maria V
AU  - Zaretskaia MV
FAU - Dimicco, Joseph A
AU  - Dimicco JA
FAU - Durant, Pamela J
AU  - Durant PJ
FAU - Ross, Christian T
AU  - Ross CT
FAU - Rusyniak, Daniel E
AU  - Rusyniak DE
LA  - eng
GR  - R01 DA026867/DA/NIDA NIH HHS/United States
GR  - R01DA026867/DA/NIDA NIH HHS/United States
GR  - C06 RR015481-010/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130808
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (Serotonin 5-HT1 Receptor Antagonists)
RN  - 0 (Serotonin Agents)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 2763-96-4 (Muscimol)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenocorticotropic Hormone/*blood
MH  - Animals
MH  - Male
MH  - Microinjections
MH  - Muscimol/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neurons/*drug effects/metabolism
MH  - Paraventricular Hypothalamic Nucleus/*drug effects/metabolism
MH  - Piperazines/pharmacology
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/*physiology
MH  - Serotonin 5-HT1 Receptor Antagonists/pharmacology
MH  - Serotonin Agents/*pharmacology
PMC - PMC3830637
MID - NIHMS514361
OTO - NOTNLM
OT  - 3,4-methylenedioxymethamphetamine
OT  - 5-HT1A
OT  - ACTH
OT  - Adrenocorticotropic hormone
OT  - Amphetamine
OT  - HPA
OT  - MDMA
OT  - PVH
OT  - Paraventricular hypothalamus
OT  - Serotonin 1a receptors
OT  - WAY
OT  - WAY-100635
OT  - aCSF
OT  - adrenocorticotropin releasing hormone
OT  - artificial cerebrospinal fluid
OT  - hypothalamic-pituitary-adrenal axis
OT  - paraventricular hypothalamus
OT  - serotonin-1a receptors
EDAT- 2013/08/13 06:00
MHDA- 2014/02/01 06:00
PMCR- 2014/10/25
CRDT- 2013/08/13 06:00
PHST- 2013/05/13 00:00 [received]
PHST- 2013/07/19 00:00 [revised]
PHST- 2013/07/30 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/02/01 06:00 [medline]
PHST- 2014/10/25 00:00 [pmc-release]
AID - S0304-3940(13)00715-5 [pii]
AID - 10.1016/j.neulet.2013.07.053 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Oct 25;555:42-6. doi: 10.1016/j.neulet.2013.07.053. Epub 2013 
      Aug 8.