PMID- 23933403
OWN - NLM
STAT- MEDLINE
DCOM- 20140817
LR  - 20221207
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 20
DP  - 2013 Dec
TI  - Association of MCP-1 -2518A/G and -362G/C variants and tuberculosis 
      susceptibility: a meta-analysis.
PG  - 1-7
LID - S1567-1348(13)00297-9 [pii]
LID - 10.1016/j.meegid.2013.08.001 [doi]
AB  - A number of studies have found that the -2518A/G and -362G/C polymorphisms in the 
      monocyte chemoattractant protein-1 (MCP-1) gene are implicated in the 
      susceptibility to tuberculosis. However, the results are inconsistent. To 
      investigate the relationship between -2518A/G and -362G/C polymorphisms in MCP-1 
      gene and the susceptibility of tuberculosis, a systematic literature search for 
      relevant articles published up to January, 2013 was conducted in the databases of 
      PubMed, Elsevier, Web of Science, Wanfang and CNKI. A total number of twenty-two 
      case-control studies that included 9365 cases and 10149 controls on two 
      single-nucleotide polymorphisms (SNPs): -2518A/G and -362G/C, were identified. 
      The results indicated that the G allele of -2518A/G polymorphism was associated 
      with increased risk of tuberculosis (GG vs. AA+AG: OR 1.455, 95% CI 1.092-1.937, 
      P = 0.01). In the subgroup analysis by ethnicity, significant elevated risks were 
      found in Asians and Americans, but not in Africans. The C allele of -362G/C 
      polymorphism was associated with resistance to tuberculosis (CC vs. GG+GC: OR 
      0.837, 95% CI 0.772-0.987, P = 0.03). This meta-analysis suggests that the G 
      allele of -2518A/G polymorphism is a risk factor for tuberculosis in Asians and 
      Americans, while not in Africans. It further indicates that C allele of -362G/C 
      polymorphism is a protective factor for tuberculosis.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Gong, Tian
AU  - Gong T
AD  - Department of Maternal and Children Health Care, School of Public Health, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Yang, Mei
AU  - Yang M
FAU - Qi, Ling
AU  - Qi L
FAU - Shen, Min
AU  - Shen M
FAU - Du, Yukai
AU  - Du Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20130808
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Chemokine CCL2/*genetics
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Tuberculosis/*genetics
OTO - NOTNLM
OT  - MCP-1
OT  - Meta-analysis
OT  - Single nucleotide polymorphism
OT  - Susceptibility
OT  - Tuberculosis
EDAT- 2013/08/13 06:00
MHDA- 2014/08/19 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/05/20 00:00 [received]
PHST- 2013/07/17 00:00 [revised]
PHST- 2013/08/02 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/08/19 06:00 [medline]
AID - S1567-1348(13)00297-9 [pii]
AID - 10.1016/j.meegid.2013.08.001 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2013 Dec;20:1-7. doi: 10.1016/j.meegid.2013.08.001. Epub 2013 
      Aug 8.