PMID- 23933499
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20130923
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 149
IP  - 3
DP  - 2013 Oct 7
TI  - Antidiabetic effect of total flavonoids from Sanguis draxonis in type 2 diabetic 
      rats.
PG  - 729-36
LID - S0378-8741(13)00536-9 [pii]
LID - 10.1016/j.jep.2013.07.035 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Sanguis draxonis (SD) is a kind of red resin 
      obtained from the wood of Dracaena cochinchinensis (Lour.) S. C. Chen (Dracaena 
      cochinchinensis). It is a Chinese traditional herb that is prescribed for the 
      handling of diabetic disorders, which is also supported by an array of scientific 
      studies published in recent years. Although chemical constituents of this plant 
      material have also been previously evaluated (Tang et al., 1995; Wei et al., 
      1998), it still remains poorly understood which constituent is the major 
      contributor to its antidiabetic activities. Moreover, very little is known about 
      the molecular mechanisms underlying antidiabetic activities of SD. Flavonoids 
      exist at a high level in SD. The aim of this study is to evaluate the 
      antidiabetic effects of total flavonoids from SD (SDF) in type 2 Diabetes 
      mellitus (T2DM) rats. MATERIALS AND METHODS: T2DM rats were induced by 4 weeks 
      high-fat diet and a singular injection of streptozotocin (STZ) (35mg/kg). Then 
      T2DM rats were treated with SDF for 21 days, using normal saline as the negative 
      control. For comparison, a standard antidiabetic drug, metformin (200mg/kg), was 
      used as a positive control. Three weeks later, relative biochemical indexes were 
      determined and histopathological examinations were performed to assess the 
      antidiabetic activities of SDF. RESULTS: SDF not only exhibited a significant 
      hypoglycemic activity, but also alleviated dyslipidemia, tissue steatosis, and 
      oxidative stress associated with T2DM. Moreover, considerable pancreatic islet 
      protecting effects could be observed after SDF treatment. Further investigations 
      revealed a potential anti-inflammation activity of SDF by determining serum 
      levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive 
      protein (CRP). CONCLUSIONS: This study demonstrates both hypoglycemic and 
      hypolipidemic effects of SDF in T2DM rats, suggesting that flavonoids are the 
      major active ingredients accounting for the antidiabetic activity of SD. 
      Alleviating chronic inflammation responses and protecting pancreatic islets are 
      possible mechanisms involved in the antidiabetic activity of SDF.
CI  - (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Chen, Fufeng
AU  - Chen F
AD  - College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, PR 
      China.
FAU - Xiong, Hui
AU  - Xiong H
FAU - Wang, Jianxia
AU  - Wang J
FAU - Ding, Xin
AU  - Ding X
FAU - Shu, Guangwen
AU  - Shu G
FAU - Mei, Zhinan
AU  - Mei Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130807
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Blood Glucose)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Flavonoids)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Resins, Plant)
RN  - 0 (sanguis draxonis)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism/pathology
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism/pathology
MH  - Dracaena/*chemistry
MH  - Drugs, Chinese Herbal/chemistry/isolation & purification/*therapeutic use
MH  - Flavonoids/isolation & purification/*therapeutic use
MH  - Glucose Tolerance Test
MH  - Hypoglycemic Agents/isolation & purification/*therapeutic use
MH  - Insulin/blood
MH  - Lipids/blood
MH  - Liver/drug effects/pathology
MH  - Male
MH  - Pancreas/drug effects/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Resins, Plant/*chemistry/isolation & purification
MH  - Streptozocin/pharmacology
MH  - Wood/chemistry
OTO - NOTNLM
OT  - C-reactive protein
OT  - CRP
OT  - D. cochinchinensis
OT  - Dracaena cochinchinensis (Lour.) S. C. Chen
OT  - Dyslipidemia
OT  - ELISA
OT  - FFA
OT  - Flavonoids
OT  - GSH
OT  - HDL-C
OT  - HE
OT  - IL-6
OT  - IR
OT  - ITT
OT  - Inflammation
OT  - LDL-C
OT  - MDA
OT  - OGTT
OT  - Oxidative stress
OT  - ROS
OT  - SD
OT  - SDF
OT  - SOD
OT  - STZ
OT  - T1DM
OT  - T2DM
OT  - TC
OT  - TG
OT  - TNF-alpha
OT  - Type 2 Diabetic mellitus
OT  - enzyme-linked immunosorbent assay
OT  - free fatty acids
OT  - glutathione
OT  - hematoxylin-eosin
OT  - high density lipoprotein cholesterol
OT  - insulin resistance
OT  - insulin tolerance test
OT  - interleukin-6
OT  - low density lipoprotein cholesterol
OT  - malondialdehyde
OT  - oral glucose tolerance test
OT  - reactive oxygen species
OT  - sanguis draxonis
OT  - streptozotocin
OT  - superoxide dismutase
OT  - total cholesterol
OT  - total flavonoids from SD
OT  - triglycerides
OT  - tumor necrosis factor-alpha
OT  - type 1 Diabetes mellitus
OT  - type 2 Diabetes mellitus
EDAT- 2013/08/13 06:00
MHDA- 2014/04/22 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/01/09 00:00 [received]
PHST- 2013/07/08 00:00 [revised]
PHST- 2013/07/24 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - S0378-8741(13)00536-9 [pii]
AID - 10.1016/j.jep.2013.07.035 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2013 Oct 7;149(3):729-36. doi: 10.1016/j.jep.2013.07.035. Epub 
      2013 Aug 7.