PMID- 23933563
OWN - NLM
STAT- MEDLINE
DCOM- 20140607
LR  - 20131015
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 128
DP  - 2013 Nov
TI  - Application of multiple parallel perfused microbioreactors: Synthesis, 
      characterization and cytotoxicity testing of the novel rare earth complexes with 
      indole acid as a ligand.
PG  - 57-67
LID - S0162-0134(13)00173-6 [pii]
LID - 10.1016/j.jinorgbio.2013.07.018 [doi]
AB  - Three novel complexes, [La(phen)2(IAA)2].NO3 (1), [Sm(phen)2(IAA)2].NO3 (2) and 
      [Sm(IBA)3(phen)].phen.HNO3.H2O (3) (phen: 1,10-phenanthroline, IAA: 
      indole-3-acetic acid, IBA: indole-3-butyric acid), were synthesized and 
      characterized with spectroscopy (infrared and UV-visible), X-ray crystal 
      diffraction and elemental analysis. Structural analysis revealed that each 
      lanthanide atom in complexes 1-3 held a distorted tricapped trigonal prism 
      geometry in a nine-coordinate mode. There were two types of coordination modes of 
      the IAA ligand in complexes 1 and 2: a mu2-eta(1):eta(2) bridging mode linking two 
      lanthanide atoms and a mu2-eta(1):eta(1) double monodentate bridging mode. There were 
      three types of coordination modes of the IBA ligand: a mu2-eta(1):eta(1) double 
      monodentate bridging mode, a mu1-eta(2) bridging mode and a mu2-eta(1):eta(2) bridging 
      mode linking two lanthanide atoms. Adjacent Sm atoms were linked via the 
      mu2-bridging carboxylate groups of the IBA ligands to generate a binuclear 
      building unit. The biological activity of the complexes was evaluated in human 
      adipose tissue-derived stem cells (hADSCs) and Chang liver cells using a multiple 
      parallel perfused microbioreactor. The results showed that cytotoxicity increased 
      as the concentrations of complexes 1-3 increased.
CI  - (c) 2013.
FAU - Guan, Qing-Lin
AU  - Guan QL
AD  - College of Chemistry and Chemical Engineering, Liaoning Normal University, No. 
      850, Huanghe Road, Dalian 116029, PR China; Regenerative Medicine Centre, First 
      Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 
      116011, PR China.
FAU - Xing, Yong-Heng
AU  - Xing YH
FAU - Liu, Jing
AU  - Liu J
FAU - Wei, Wen-Juan
AU  - Wei WJ
FAU - Zhang, Rui
AU  - Zhang R
FAU - Wang, Xuan
AU  - Wang X
FAU - Bai, Feng-Ying
AU  - Bai FY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130719
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Coordination Complexes)
RN  - 0 (Indoleacetic Acids)
RN  - 0 (Indoles)
RN  - 0 (Lanthanoid Series Elements)
RN  - 061SKE27JP (indolebutyric acid)
RN  - 6U1S09C61L (indoleacetic acid)
SB  - IM
MH  - Adipose Tissue/cytology
MH  - Apoptosis/drug effects
MH  - *Bioreactors
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Coordination Complexes/chemical synthesis/*chemistry/*pharmacology
MH  - Crystallography, X-Ray
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Indoleacetic Acids/*chemistry
MH  - Indoles/*chemistry
MH  - Lanthanoid Series Elements/*chemistry
MH  - Liver/cytology
MH  - Models, Molecular
MH  - Molecular Structure
MH  - Perfusion
MH  - Spectrophotometry
MH  - Stem Cells/cytology/drug effects
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - Cytotoxicity
OT  - Indole acid
OT  - Lanthanide complexes
OT  - Microbioreactors
OT  - Molecular structure
EDAT- 2013/08/13 06:00
MHDA- 2014/06/08 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/01/09 00:00 [received]
PHST- 2013/07/02 00:00 [revised]
PHST- 2013/07/08 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/06/08 06:00 [medline]
AID - S0162-0134(13)00173-6 [pii]
AID - 10.1016/j.jinorgbio.2013.07.018 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2013 Nov;128:57-67. doi: 10.1016/j.jinorgbio.2013.07.018. Epub 
      2013 Jul 19.