PMID- 23934685
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20220410
IS  - 1439-0973 (Electronic)
IS  - 0300-8126 (Linking)
VI  - 42
IP  - 1
DP  - 2014 Feb
TI  - Reduction of central venous line-associated bloodstream infection rates by using 
      a chlorhexidine-containing dressing.
PG  - 155-9
LID - 10.1007/s15010-013-0519-7 [doi]
AB  - PURPOSE: The reduction of central venous line (CVL)-associated bloodstream 
      infections (CLABSIs) is generally advocated. However, despite implementing 
      infection prevention recommendations, CLABSI rates remain high at some 
      institutions. Therefore, a chlorhexidine-containing dressing should be assessed 
      for its potential for infection reduction, adverse events (AEs) and 
      practicability. METHODS: The number of CVLs, CVL days, CLABSIs and CLABSI rates 
      with regard to the kind of dressing (standard vs. chlorhexidine-containing) were 
      documented from November 2010 to may 2012 (1,298 patients with 12,220 CVL days) 
      at two intensive care units (ICUs) and compared to historical controls. The 
      practicability and safety of the chlorhexidine-containing dressing and reasons 
      for not using this dressing were assessed. RESULTS: Forty CLABSIs occurred in 34 
      patients, resulting in a significantly lower overall CLABSI rate in patients with 
      the chlorhexidine-containing dressing [1.51/1,000 CVL days; confidence interval 
      (CI): 0.75-2.70] compared to patients with the standard dressing (5.87/1,000 CVL 
      days; CI: 3.93-8.43; p < 0.0001). The CLABSI rate in historical controls 
      receiving the standard dressing was 6.2/1,000 CVL days. The main reason for not 
      using chlorhexidine-containing dressing was bleeding at the insertion site. AEs 
      occurred in five patients and represented self-healing skin macerations (3 cases) 
      and superficial skin necrosis (2 cases). CONCLUSIONS: In case of high CLABSI 
      rates despite the implementation of standard recommendations, our findings 
      suggest that a chlorhexidine-containing dressing safely decreases CLABSI rates.
FAU - Scheithauer, S
AU  - Scheithauer S
AD  - Department of Infection Control and Infectious Diseases, University Hospital 
      Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany, 
      sscheithauer@ukaachen.de.
FAU - Lewalter, K
AU  - Lewalter K
FAU - Schroder, J
AU  - Schroder J
FAU - Koch, A
AU  - Koch A
FAU - Hafner, H
AU  - Hafner H
FAU - Krizanovic, V
AU  - Krizanovic V
FAU - Nowicki, K
AU  - Nowicki K
FAU - Hilgers, R-D
AU  - Hilgers RD
FAU - Lemmen, S W
AU  - Lemmen SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130809
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
RN  - 0 (Disinfectants)
RN  - R4KO0DY52L (Chlorhexidine)
SB  - IM
MH  - Aged
MH  - *Bandages
MH  - Catheter-Related Infections/*epidemiology/*prevention & control
MH  - Catheterization, Central Venous/*adverse effects/methods
MH  - Chlorhexidine/*therapeutic use
MH  - Disinfectants/*therapeutic use
MH  - Female
MH  - Humans
MH  - Infection Control/*methods
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
EDAT- 2013/08/13 06:00
MHDA- 2014/09/23 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/03/19 00:00 [received]
PHST- 2013/07/25 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - 10.1007/s15010-013-0519-7 [doi]
PST - ppublish
SO  - Infection. 2014 Feb;42(1):155-9. doi: 10.1007/s15010-013-0519-7. Epub 2013 Aug 9.