PMID- 23934992
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20220318
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Linking)
VI  - 6
IP  - 5
DP  - 2013 Sep
TI  - Myocardial fibrosis as a key determinant of left ventricular remodeling in 
      idiopathic dilated cardiomyopathy: a contrast-enhanced cardiovascular magnetic 
      study.
PG  - 790-9
LID - 10.1161/CIRCIMAGING.113.000438 [doi]
AB  - BACKGROUND: In idiopathic dilated cardiomyopathy, there are scarce data on the 
      influence of late gadolinium enhancement (LGE) assessed by cardiovascular 
      magnetic resonance on left ventricular (LV) remodeling. METHODS AND RESULTS: 
      Fifty-eight consecutive patients with idiopathic dilated cardiomyopathy underwent 
      baseline clinical, biohumoral, and instrumental workup. Medical therapy was 
      optimized after study enrollment. Cardiovascular magnetic resonance was used to 
      assess ventricular volumes, function, and LGE extent at baseline and 24-month 
      follow-up. LV reverse remodeling (RR) was defined as an increase in LV ejection 
      fraction >/=10 U, combined with a decrease in LV end-diastolic volume >/=10% at 
      follow-up. DeltaLGE extent was the difference in LGE extent between follow-up and 
      baseline. LV-RR was observed in 22 patients (38%). Multivariate regression 
      analysis showed that the absence of LGE at baseline cardiovascular magnetic 
      resonance was a strong predictor of LV-RR (odds ratio, 10.857 [95% confidence 
      interval, 1.844-63.911]; P=0.008) after correction for age, heart rate, New York 
      Heart Association class, LV volumes, and LV and right ventricular ejection 
      fractions. All patients with baseline LGE (n=26; 45%) demonstrated LGE at 
      follow-up, and no patient without baseline LGE developed LGE at follow-up. In 
      LGE-positive patients, there was an increase in LGE extent over time (P=0.034), 
      which was inversely related to LV ejection fraction variation (Spearman rho, 
      -0.440; P=0.041). Five patients showed an increase in LGE extent >75th percentile 
      of DeltaLGE extent, and among these none experienced LV-RR and 4 had a decrease in LV 
      ejection fraction >/=10 U at follow-up. CONCLUSIONS: In patients with idiopathic 
      dilated cardiomyopathy, the absence of LGE at baseline is a strong independent 
      predictor of LV-RR at 2-year follow-up, irrespective of the initial clinical 
      status and the severity of ventricular dilatation and dysfunction. The increase 
      in LGE extent during follow-up was associated with progressive LV dysfunction.
FAU - Masci, Pier Giorgio
AU  - Masci PG
AD  - Fondazione CNR/Regione Toscana "G. Monasterio," Pisa, Italy.
FAU - Schuurman, Robert
AU  - Schuurman R
FAU - Andrea, Barison
AU  - Andrea B
FAU - Ripoli, Andrea
AU  - Ripoli A
FAU - Coceani, Michele
AU  - Coceani M
FAU - Chiappino, Sara
AU  - Chiappino S
FAU - Todiere, Giancarlo
AU  - Todiere G
FAU - Srebot, Vera
AU  - Srebot V
FAU - Passino, Claudio
AU  - Passino C
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
FAU - Emdin, Michele
AU  - Emdin M
FAU - Lombardi, Massimo
AU  - Lombardi M
LA  - eng
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20130809
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - Circ Cardiovasc Imaging. 2013 Nov;6(6):e77. PMID: 24254487
CIN - Circ Cardiovasc Imaging. 2013 Nov;6(6):e78. PMID: 24254488
CIN - Circ Cardiovasc Imaging. 2013 Nov;6(6):e79. PMID: 24254489
MH  - Adult
MH  - Aged
MH  - Bayes Theorem
MH  - Cardiomyopathy, Dilated/*diagnosis/pathology/physiopathology
MH  - Chi-Square Distribution
MH  - *Contrast Media
MH  - Female
MH  - Fibrosis
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Logistic Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardium/*pathology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/*diagnosis/pathology/physiopathology
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
MH  - *Ventricular Remodeling
OTO - NOTNLM
OT  - cardiomyopathy, dilated
OT  - myocardial fibrosis
OT  - ventricular remodeling
EDAT- 2013/08/13 06:00
MHDA- 2013/11/15 06:00
CRDT- 2013/08/13 06:00
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
AID - CIRCIMAGING.113.000438 [pii]
AID - 10.1161/CIRCIMAGING.113.000438 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2013 Sep;6(5):790-9. doi: 
      10.1161/CIRCIMAGING.113.000438. Epub 2013 Aug 9.