PMID- 23935580
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130812
LR  - 20211021
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 7
DP  - 2013
TI  - Three ways in which midline regions contribute to self-evaluation.
PG  - 450
LID - 10.3389/fnhum.2013.00450 [doi]
LID - 450
AB  - An integration of existing research and newly conducted psychophysiological 
      interaction (PPI) connectivity analyses suggest a new framework for understanding 
      the contribution of midline regions to social cognition. Recent meta-analyses 
      suggest that there are no midline regions that are exclusively associated with 
      self-processing. Whereas medial prefrontal cortex (MPFC) is broadly modulated by 
      self-processing, subdivisions within MPFC are differentially modulated by the 
      evaluation of close others (ventral MPFC: BA 10/32) and the evaluation of other 
      social targets (dorsal MPFC: BA 9/32). The role of DMPFC in social cognition may 
      also be less uniquely social than previously thought; it may be better 
      characterized as a region that indexes certainty about evaluation rather than 
      previously considered social mechanisms (i.e., correction of self-projection). 
      VMPFC, a region often described as an important mediator of socioemotional 
      significance, may instead perform a more cognitive role by reflecting the type of 
      information brought to bear on evaluations of people we know well. Furthermore, 
      the new framework moves beyond MPFC and hypothesizes that two other midline 
      regions, ventral anterior cingulate cortex (VACC: BA 25) and medial orbitofrontal 
      cortex (MOFC: BA 11), aid motivational influences on social cognition. Despite 
      the central role of motivation in psychological models of self-perception, neural 
      models have largely ignored the topic. Positive connectivity between VACC and 
      MOFC may mediate bottom-up sensitivity to information based on its potential for 
      helping us evaluate ourselves or others the way we want. As connectivity becomes 
      more positive with striatum and less positive with middle frontal gyrus (BA 
      9/44), MOFC mediates top-down motivational influences by adjusting the standards 
      we bring to bear on evaluations of ourselves and other people.
FAU - Flagan, Taru
AU  - Flagan T
AD  - Department of Psychology, University of Texas at Austin , Austin, TX , USA.
FAU - Beer, Jennifer S
AU  - Beer JS
LA  - eng
PT  - Journal Article
DEP - 20130802
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC3731671
OTO - NOTNLM
OT  - frontal lobe
OT  - motivation
OT  - optimistic bias
OT  - person perception
OT  - self
OT  - self-projection
OT  - social cognition
EDAT- 2013/08/13 06:00
MHDA- 2013/08/13 06:01
PMCR- 2013/01/01
CRDT- 2013/08/13 06:00
PHST- 2013/05/01 00:00 [received]
PHST- 2013/07/21 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2013/08/13 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2013.00450 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2013 Aug 2;7:450. doi: 10.3389/fnhum.2013.00450. eCollection 
      2013.