PMID- 23935975
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 7
DP  - 2013
TI  - Altered white matter architecture in BDNF met carriers.
PG  - e69290
LID - 10.1371/journal.pone.0069290 [doi]
LID - e69290
AB  - Brain-derived neurotrophic factor (BDNF) modulates the pruning of synaptically 
      silent axonal arbors. The Met allele of the BDNF gene is associated with a 
      reduction in the neurotrophin's activity-dependent release. We used 
      diffusion-weighted imaging to construct structural brain networks for 36 healthy 
      subjects with known BDNF genotypes. Through permutation testing we discovered 
      clear differences in connection strength between subjects carrying the Met allele 
      and those homozygotic for the Val allele. We trained a Gaussian process 
      classifier capable of identifying the subjects' allelic group with 86% accuracy 
      and high predictive value. In Met carriers structural connectivity was greatly 
      increased throughout the forebrain, particularly in connections corresponding to 
      the anterior and superior corona radiata as well as corticothalamic and 
      corticospinal projections from the sensorimotor, premotor, and prefrontal 
      portions of the internal capsule. Interhemispheric connectivity was also 
      increased via the corpus callosum and anterior commissure, and extremely high 
      connectivity values were found between inferior medial frontal polar regions via 
      the anterior forceps. We propose that the decreased availability of BDNF leads to 
      deficits in axonal maintenance in carriers of the Met allele, and that this 
      produces mesoscale changes in white matter architecture.
FAU - Ziegler, Erik
AU  - Ziegler E
AD  - Cyclotron Research Centre, Universite de Liege, Liege, Belgium.
FAU - Foret, Ariane
AU  - Foret A
FAU - Mascetti, Laura
AU  - Mascetti L
FAU - Muto, Vincenzo
AU  - Muto V
FAU - Le Bourdiec-Shaffii, Anahita
AU  - Le Bourdiec-Shaffii A
FAU - Stender, Johan
AU  - Stender J
FAU - Balteau, Evelyne
AU  - Balteau E
FAU - Dideberg, Vinciane
AU  - Dideberg V
FAU - Bours, Vincent
AU  - Bours V
FAU - Maquet, Pierre
AU  - Maquet P
FAU - Phillips, Christophe
AU  - Phillips C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130731
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Algorithms
MH  - Alleles
MH  - Brain/anatomy & histology/metabolism/*physiology
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Corpus Callosum/anatomy & histology/metabolism/physiology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Internal Capsule/anatomy & histology/metabolism/physiology
MH  - Linkage Disequilibrium
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Methionine/*genetics
MH  - Models, Neurological
MH  - Nerve Fibers/metabolism/physiology
MH  - Nerve Net/anatomy & histology/metabolism/physiology
MH  - Polymorphism, Single Nucleotide
MH  - Valine/*genetics
MH  - Young Adult
PMC - PMC3729843
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/08/13 06:00
MHDA- 2014/04/22 06:00
PMCR- 2013/07/31
CRDT- 2013/08/13 06:00
PHST- 2013/02/19 00:00 [received]
PHST- 2013/06/07 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
PHST- 2013/07/31 00:00 [pmc-release]
AID - PONE-D-13-07542 [pii]
AID - 10.1371/journal.pone.0069290 [doi]
PST - epublish
SO  - PLoS One. 2013 Jul 31;8(7):e69290. doi: 10.1371/journal.pone.0069290. Print 2013.