PMID- 23936694
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130812
LR  - 20211021
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2013
DP  - 2013
TI  - Early Death in Two Patients with Acute Promyelocytic Leukemia Presenting the bcr3 
      Isoform, FLT3-ITD Mutation, and Elevated WT1 Level.
PG  - 896394
LID - 10.1155/2013/896394 [doi]
LID - 896394
AB  - Despite major advances in the treatment of acute promyelocytic leukemia (APL), 
      the problem of early death (ED) remains unsolved. Alongside the currently known 
      clinical and hematological risk factors, prognostic significance has been 
      attributed to internal tandem duplication mutations of the fms-like tyrosine 
      kinase-3 (FLT3-ITD), hypogranular variant morphology, and the bcr-3 isoform of 
      PML-RAR alpha . We describe premature death of two patients with the hypogranular 
      variant of APL who presented remarkably high expression levels of Wilms' tumor 
      gene (WT1). Our results point to WT1 as an important prognostic factor of ED that 
      needs to be promptly evaluated in all newly diagnosed cases of APL.
FAU - Greco, Marianna
AU  - Greco M
AD  - Hematology Unit and Bone Marrow Transplantation Center, "R. Binaghi" Hospital, 
      Via Is Guadazzonis 3, 09126 Cagliari, Italy.
FAU - Caocci, Giovanni
AU  - Caocci G
FAU - Ledda, Antonio
AU  - Ledda A
FAU - Vacca, Adriana
AU  - Vacca A
FAU - Arras, Marcella
AU  - Arras M
FAU - Celeghini, Ivana
AU  - Celeghini I
FAU - La Nasa, Giorgio
AU  - La Nasa G
LA  - eng
PT  - Journal Article
DEP - 20130707
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC3722971
EDAT- 2013/08/13 06:00
MHDA- 2013/08/13 06:01
PMCR- 2013/07/07
CRDT- 2013/08/13 06:00
PHST- 2013/05/08 00:00 [received]
PHST- 2013/05/29 00:00 [accepted]
PHST- 2013/08/13 06:00 [entrez]
PHST- 2013/08/13 06:00 [pubmed]
PHST- 2013/08/13 06:01 [medline]
PHST- 2013/07/07 00:00 [pmc-release]
AID - 10.1155/2013/896394 [doi]
PST - ppublish
SO  - Case Rep Hematol. 2013;2013:896394. doi: 10.1155/2013/896394. Epub 2013 Jul 7.