PMID- 23937197
OWN - NLM
STAT- MEDLINE
DCOM- 20140416
LR  - 20220316
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 10
IP  - 4
DP  - 2013 Nov
TI  - Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult 
      neurogenesis to mediate recovery from cognitive impairment.
PG  - 304-15
AB  - Radix Angelica Sinensis (RAS) has beneficial effects in patients suffering from 
      cognitive impairment associated with chronic cerebral hypoperfusion. It has 
      previously been demonstrated that RAS prevents the neurotoxic effects of 
      beta-amyloid (Abeta) in vitro, protects from injuries due to oxidative stress, 
      inflammation and apoptosis and ameliorates scopolamine-induced amnesia in rats. 
      Here, we studied the effects of RAS on cognitive improvement and neurogenic 
      enhancement and examined the possible underlying mechanisms in a rat model with 
      permanent bilateral common carotid artery occlusion, which serves as a model of 
      chronic cerebral hypoperfusion-related neurodegenerative diseases. RAS enhances 
      adult neurogenesis in the hippocampus following chronic cerebral hypoperfusion 
      and improves the cognitive decline associated with hypoperfusion. Long-term 
      ablation of adult hippocampal neurogenesis through cranial irradiation abolishes 
      the protective effects of RAS on cognition. Furthermore, administration of RAS 
      restores the decrease of brain-derived neurotrophic factor (BDNF) expression, the 
      phosphorylation of cAMP-responsive element binding protein (CREB) and the 
      glutamic acid decarboxylase 65 (GAD65) staining intensity in rats with chronic 
      cerebral hypoperfusion. The present study supports the hypothesis that adult 
      neurogenesis is required for RAS to facilitate recovery from the cognitive 
      impairment induced by chronic cerebral hypoperfusion, while neurogenic 
      enhancement secondary to RAS treatment may be due to increased BDNF and 
      phosphorylated cAMP-responsive element binding protein (p-CREB) levels and 
      increased gamma-aminobutyric acid (GABA) expression. Based on the possible mechanisms 
      suggested by the present study, this well-known traditional medicine may 
      represent a candidate therapeutic agent for the treatment of dementia associated 
      with vascular injury.
FAU - Xin, Jiawei
AU  - Xin J
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No.169, Donghu 
      Road, Wuhan 430071, Hubei, China. wdsjkx@163.com.
FAU - Zhang, Junjian
AU  - Zhang J
FAU - Yang, Ying
AU  - Yang Y
FAU - Deng, Min
AU  - Deng M
FAU - Xie, Xiaofeng
AU  - Xie X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (Drugs, Chinese Herbal)
RN  - 4431-01-0 (ligustilide)
RN  - B66F4574UG (angelicae sinensis extract)
RN  - OL659KIY4X (4-Butyrolactone)
SB  - IM
MH  - 4-Butyrolactone/analogs & derivatives/pharmacology
MH  - Adult Stem Cells/cytology/drug effects
MH  - Angelica sinensis/chemistry
MH  - Animals
MH  - Blotting, Western
MH  - Cell Differentiation/drug effects
MH  - Cognition Disorders/etiology
MH  - Cranial Irradiation/adverse effects
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/chemistry/*pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Neural Stem Cells/cytology/drug effects
MH  - *Neurodegenerative Diseases/complications
MH  - Neurogenesis/*drug effects
MH  - Rats
MH  - Rats, Wistar
EDAT- 2013/08/14 06:00
MHDA- 2014/04/17 06:00
CRDT- 2013/08/14 06:00
PHST- 2013/07/21 00:00 [received]
PHST- 2013/08/07 00:00 [revised]
PHST- 2013/08/11 00:00 [accepted]
PHST- 2013/08/14 06:00 [entrez]
PHST- 2013/08/14 06:00 [pubmed]
PHST- 2014/04/17 06:00 [medline]
AID - 55130 [pii]
AID - 10.2174/15672026113109990023 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2013 Nov;10(4):304-15. doi: 10.2174/15672026113109990023.