PMID- 23939919
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20221207
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 169
IP  - 5
DP  - 2013 Nov
TI  - Pathogenesis of type 2 diabetes in South Asians.
PG  - R99-R114
LID - 10.1530/EJE-13-0307 [doi]
AB  - The risk of developing type 2 diabetes mellitus (T2DM) is exceptionally high 
      among both native and migrant South Asians. T2DM occurs more often and at a 
      younger age and lower BMI, and the risk of coronary artery and cerebrovascular 
      disease, and renal complications is higher for South Asians compared with people 
      of White Caucasian descent. The high prevalence of T2DM and its related 
      complications in South Asians, which comprise one-fifth of the total world's 
      population, poses a major health and socioeconomic burden. The underlying cause 
      of this excess risk, however, is still not completely understood. Therefore, 
      gaining insight into the pathogenesis of T2DM in South Asians is of great 
      importance. The predominant mechanism, in this ethnicity seems to be insulin 
      resistance (IR) rather than an impaired beta-cell function. In this systematic 
      review, we describe several possible mechanisms that may underlie or contribute 
      to the increased IR observed in South Asians.
FAU - Bakker, Leontine E H
AU  - Bakker LE
AD  - Department of General Internal Medicine and Endocrinology Walaeus Library, Leiden 
      University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
FAU - Sleddering, Maria A
AU  - Sleddering MA
FAU - Schoones, Jan W
AU  - Schoones JW
FAU - Meinders, A Edo
AU  - Meinders AE
FAU - Jazet, Ingrid M
AU  - Jazet IM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20131001
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Cholesterol, HDL)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adipose Tissue/physiopathology
MH  - Asian People/*statistics & numerical data
MH  - Biological Evolution
MH  - Body Composition/physiology
MH  - Cholesterol, HDL/physiology
MH  - Diabetes Mellitus, Type 2/*etiology/genetics
MH  - Diet
MH  - Exercise
MH  - Humans
MH  - Life Style
MH  - Muscle, Skeletal/physiopathology
MH  - Nitric Oxide/metabolism
MH  - White People
EDAT- 2013/08/14 06:00
MHDA- 2013/11/20 06:00
CRDT- 2013/08/14 06:00
PHST- 2013/08/14 06:00 [entrez]
PHST- 2013/08/14 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - EJE-13-0307 [pii]
AID - 10.1530/EJE-13-0307 [doi]
PST - epublish
SO  - Eur J Endocrinol. 2013 Oct 1;169(5):R99-R114. doi: 10.1530/EJE-13-0307. Print 
      2013 Nov.