PMID- 23941062
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20211021
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 14
IP  - 1
DP  - 2013 Aug 13
TI  - TRPA1 and other TRP channels in migraine.
PG  - 71
LID - 10.1186/1129-2377-14-71 [doi]
AB  - Ever since their identification, interest in the role of transient receptor 
      potential (TRP) channels in health and disease has steadily increased. Robust 
      evidence has underlined the role of TRP channels expressed in a subset of primary 
      sensory neurons of the trigeminal ganglion to promote, by neuronal excitation, 
      nociceptive responses, allodynia and hyperalgesia. In particular, the TRP 
      vanilloid 1 (TRPV1) and the TRP ankyrin 1 (TRPA1) are expressed in nociceptive 
      neurons, which also express the sensory neuropeptides, tachykinins, and 
      calcitonin gene-related peptide (CGRP), which mediate neurogenic inflammatory 
      responses. Of interest, CGRP released from the trigeminovascular network of 
      neurons is currently recognized as a main contributing mechanism of migraine 
      attack. The ability of TRPA1 to sense and to be activated by an unprecedented 
      series of exogenous and endogenous reactive molecules has now been extensively 
      documented. Several of the TRPA1 activators are also known as triggers of 
      migraine attack. Thus, TRP channels, and particularly TRPA1, may be proposed as 
      novel pathways in migraine pathophysiology and as possible new targets for its 
      treatment.
FAU - Benemei, Silvia
AU  - Benemei S
AD  - Headache Center and Clinical Pharmacology Unit, Department of Health Sciences, 
      Careggi University Hospital, University of Florence, viale Pieraccini 6, Florence 
      50139, Italy. silvia.benemei@unifi.it.
FAU - De Cesaris, Francesco
AU  - De Cesaris F
FAU - Fusi, Camilla
AU  - Fusi C
FAU - Rossi, Eleonora
AU  - Rossi E
FAU - Lupi, Chiara
AU  - Lupi C
FAU - Geppetti, Pierangelo
AU  - Geppetti P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130813
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
RN  - 0 (Calcium Channels)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (TRPA1 Cation Channel)
RN  - 0 (TRPA1 protein, human)
RN  - 0 (Transient Receptor Potential Channels)
SB  - IM
MH  - Animals
MH  - Calcium Channels/*metabolism
MH  - Humans
MH  - Migraine Disorders/*metabolism/*physiopathology
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neuralgia/metabolism/physiopathology
MH  - Neurons/metabolism
MH  - TRPA1 Cation Channel
MH  - Transient Receptor Potential Channels/*metabolism
PMC - PMC3844362
EDAT- 2013/08/15 06:00
MHDA- 2014/05/13 06:00
PMCR- 2013/01/01
CRDT- 2013/08/15 06:00
PHST- 2013/05/22 00:00 [received]
PHST- 2013/08/10 00:00 [accepted]
PHST- 2013/08/15 06:00 [entrez]
PHST- 2013/08/15 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 1129-2377-14-71 [pii]
AID - 10.1186/1129-2377-14-71 [doi]
PST - epublish
SO  - J Headache Pain. 2013 Aug 13;14(1):71. doi: 10.1186/1129-2377-14-71.