PMID- 23941566
OWN - NLM
STAT- MEDLINE
DCOM- 20140610
LR  - 20131030
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 23
IP  - 9
DP  - 2013 Nov
TI  - Effects of diphenyl diselenide and diphenyl ditellurite on chicken embryo 
      development.
PG  - 660-4
LID - 10.3109/15376516.2013.834015 [doi]
AB  - Studies of our group has demonstrated that (PhSe)2 plays some pharmacologic 
      activities. In addition, it is possible that this compound would be an 
      alternative source of organic selenium in animal foods. However, previous works 
      showed that diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 are 
      toxic for mammals, but their undesirable effects were never tested in avian 
      models. Then, the present study was carried to examine the possible teratogenic 
      effects of (PhSe)2 and (PhTe)2 on chicken embryo development. The eggs were 
      injected with (PhSe)2 at 0, 1 and 10 nmol or with (PhTe)2 at 4 nmol. The control 
      was injected with 10 microl of soya bean oil (vehicle). In order to determine the 
      possible toxic effect of these chemicals, we measure the embryo dimensions, the 
      encephalon, heart and liver weight, thiobarturic acid reactive species (TBARS) 
      level and the delta-aminonevulinate dehydratase (ALA-D) activity. (PhSe)2 and (PhTe)2 
      did not affect the embryo dimensions. Treatment with (PhSe)2 at 10 nmol per egg 
      caused a increase on TBARS level and on ALA-D activity of the liver tissue, 
      whereas (PhTe)2 decreased encephalon weight, had a tendency to increase to 
      increase TBARS level but did not affect ALA-D activity. Taken together, these 
      results indicate that (PhSe)2 and (PhTe)2 are slightly toxic for chicken embryos. 
      Furthermore, (PhTe)2 caused a decrease in encephalon, which indicates its 
      neurotoxicity. Finally, these results indicate that (PhTe)2 seems not be 
      promissory for therapeutic applications, whereas (PhSe)2 could be of clinical 
      and/or nutritional concern, which will be target for further researches.
FAU - Prauchner, Carlos Andre
AU  - Prauchner CA
AD  - Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade 
      Federal de Santa Maria , Santa Maria, Rio Grande do Sul , Brasil.
FAU - Prestes, Alessandro de Souza
AU  - Prestes Ade S
FAU - Nogueira, Cristina W
AU  - Nogueira CW
FAU - Rocha, Joao B T
AU  - Rocha JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130906
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Benzene Derivatives)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Teratogens)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (diphenylditelluride)
RN  - 1666-13-3 (diphenyldiselenide)
RN  - 88755TAZ87 (Aminolevulinic Acid)
SB  - IM
MH  - Aminolevulinic Acid/metabolism
MH  - Animals
MH  - Benzene Derivatives/chemistry/*toxicity
MH  - Brain/drug effects/embryology/metabolism
MH  - Chick Embryo
MH  - Dose-Response Relationship, Drug
MH  - Embryonic Development/*drug effects
MH  - Heart/drug effects/embryology
MH  - Liver/drug effects/embryology/metabolism
MH  - Molecular Structure
MH  - Organ Size/drug effects
MH  - Organometallic Compounds/chemistry/*toxicity
MH  - Organoselenium Compounds/chemistry/*toxicity
MH  - Teratogens/chemistry/*toxicity
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2013/08/15 06:00
MHDA- 2014/06/11 06:00
CRDT- 2013/08/15 06:00
PHST- 2013/08/15 06:00 [entrez]
PHST- 2013/08/15 06:00 [pubmed]
PHST- 2014/06/11 06:00 [medline]
AID - 10.3109/15376516.2013.834015 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2013 Nov;23(9):660-4. doi: 10.3109/15376516.2013.834015. 
      Epub 2013 Sep 6.