PMID- 23941739
OWN - NLM
STAT- MEDLINE
DCOM- 20140416
LR  - 20131001
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 126
IP  - 2
DP  - 2013
TI  - Three-month treatment with adaptive servoventilation improves cardiac function 
      and physical activity in patients with chronic heart failure and cheyne-stokes 
      respiration: a prospective randomized controlled trial.
PG  - 81-90
LID - 10.1159/000350826 [doi]
AB  - BACKGROUND: Cheyne-Stokes respiration frequently occurs in patients with 
      congestive heart failure (CHF). Adaptive servoventilation (ASV) is a novel 
      therapy with potential benefits. This prospective randomized trial investigated 
      the effects of ASV on myocardial function and physical capacity. METHODS: 
      Patients with severe CHF, despite optimal cardiac medication and/or left 
      ventricular ejection fraction (LVEF) </=40% and Cheyne-Stokes breathing for >25% of 
      sleeping time were included. Fifty-one patients, age 57-81 years (4 were women), 
      were randomized to either an ASV or a control group; 30 patients completed the 
      study (15 from each group). The primary end point was any change in LVEF. The 
      secondary end points were alterations in physical capacity according to the 6-min 
      walk test or the New York Heart Association (NYHA) class. RESULTS: In the 
      ASV-treatment group, LVEF improved from baseline (32 +/- 11%) to study end (36 +/- 
      13%), p = 0.013. The 6-min walk test improved from 377 +/- 115 to 430 +/- 123 m (p = 
      0.014) and the NYHA class from 3.2 (3.0-3.0) to 2.0 (2.0-3.0) (p < 0.001). No 
      changes occurred in the control group. CONCLUSION: Three months of ASV treatment 
      improved LVEF and physical capacity in CHF patients with Cheyne-Stokes 
      respiration. These results suggest that ASV may be a beneficial supplement to 
      standard medication in these patients.
CI  - (c) 2013 S. Karger AG, Basel.
FAU - Hetland, Arild
AU  - Hetland A
AD  - University of Oslo, Oslo, Norway.
FAU - Haugaa, Kristina H
AU  - Haugaa KH
FAU - Olseng, Margareth
AU  - Olseng M
FAU - Gjesdal, Ola
AU  - Gjesdal O
FAU - Ross, Stian
AU  - Ross S
FAU - Saberniak, Jorg
AU  - Saberniak J
FAU - Jacobsen, Morten B
AU  - Jacobsen MB
FAU - Edvardsen, Thor
AU  - Edvardsen T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130809
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cheyne-Stokes Respiration/complications/physiopathology/*therapy
MH  - Exercise Tolerance/physiology
MH  - Female
MH  - Heart Failure/complications/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Compliance
MH  - Positive-Pressure Respiration/*methods
MH  - Prospective Studies
MH  - Stroke Volume/physiology
MH  - Treatment Outcome
MH  - Walking/physiology
EDAT- 2013/08/15 06:00
MHDA- 2014/04/17 06:00
CRDT- 2013/08/15 06:00
PHST- 2012/10/30 00:00 [received]
PHST- 2013/03/19 00:00 [accepted]
PHST- 2013/08/15 06:00 [entrez]
PHST- 2013/08/15 06:00 [pubmed]
PHST- 2014/04/17 06:00 [medline]
AID - 000350826 [pii]
AID - 10.1159/000350826 [doi]
PST - ppublish
SO  - Cardiology. 2013;126(2):81-90. doi: 10.1159/000350826. Epub 2013 Aug 9.