PMID- 23941822
OWN - NLM
STAT- MEDLINE
DCOM- 20140324
LR  - 20220331
IS  - 1421-9670 (Electronic)
IS  - 0250-8095 (Linking)
VI  - 38
IP  - 2
DP  - 2013
TI  - Antineutrophil cytoplasmic antibody vasculitis associated with influenza 
      vaccination.
PG  - 174-8
LID - 10.1159/000354084 [doi]
AB  - BACKGROUND: Administration of influenza vaccines has been associated with the 
      development of autoantibodies and autoimmune rheumatic disease. PATIENTS: We 
      discuss 2 patients who developed antineutrophil cytoplasmic antibody-associated 
      vasculitis (AAV) in temporal association with influenza immunization. AAV was 
      diagnosed 2 and 4 weeks after immunization in these patients. Both patients had 
      renal involvement with one requiring dialysis. Both patients were treated with 
      cyclophosphamide and corticosteroids, and plasmapheresis was added to the 
      immunosuppressive regimen in one patient with dialysis-dependent renal failure. 
      Both patients achieved disease remission. The patient with initial 
      dialysis-dependent renal failure reached end-stage renal disease. There are 6 
      previous cases of AAV in the literature described in temporal association with 
      administration of influenza vaccines. CONCLUSION: A causal role of vaccines in 
      AAV cannot be confirmed with these case reports. The temporality suggests that 
      the influenza vaccine may be a triggering factor for induction of vasculitis in 
      predisposed individuals. We review the literature on reported cases of AAV 
      following influenza vaccine administration and discuss possible mechanisms for 
      influenza vaccine-associated AAV.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Duggal, Tanu
AU  - Duggal T
AD  - Department of Medicine, Sinai Hospital of Baltimore, Baltimore, Md., USA.
FAU - Segal, Paul
AU  - Segal P
FAU - Shah, Megha
AU  - Shah M
FAU - Carter-Monroe, Naima
AU  - Carter-Monroe N
FAU - Manoharan, Pradeep
AU  - Manoharan P
FAU - Geetha, Duvuru
AU  - Geetha D
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130806
PL  - Switzerland
TA  - Am J Nephrol
JT  - American journal of nephrology
JID - 8109361
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Influenza Vaccines)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*etiology/*immunology
MH  - Antibodies, Antineutrophil Cytoplasmic/*immunology
MH  - Biopsy
MH  - Cyclophosphamide/therapeutic use
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Influenza Vaccines/*adverse effects
MH  - Influenza, Human/prevention & control
MH  - Kidney Failure, Chronic/complications/etiology
MH  - Male
MH  - Middle Aged
MH  - Remission Induction
MH  - Renal Dialysis/methods
MH  - Time Factors
EDAT- 2013/08/15 06:00
MHDA- 2014/03/25 06:00
CRDT- 2013/08/15 06:00
PHST- 2013/08/15 06:00 [entrez]
PHST- 2013/08/15 06:00 [pubmed]
PHST- 2014/03/25 06:00 [medline]
AID - 000354084 [pii]
AID - 10.1159/000354084 [doi]
PST - ppublish
SO  - Am J Nephrol. 2013;38(2):174-8. doi: 10.1159/000354084. Epub 2013 Aug 6.