PMID- 2394238
OWN - NLM
STAT- MEDLINE
DCOM- 19901009
LR  - 20191029
IS  - 0232-1513 (Print)
IS  - 0232-1513 (Linking)
VI  - 39
IP  - 1
DP  - 1990
TI  - Nicotine increases human polymorphonuclear leukocytes chemotactic response--a 
      possible additional mechanism of lung injury in cigarette smokers.
PG  - 37-43
AB  - Human polymorphonuclear leukocytes (PMNL) which are a potential source of 
      proteolytic enzymes and reactive oxidant species contribute to the development of 
      pulmonary emphysema in cigarette smokers. We found that nicotine at 
      concentrations that occur in smokers' plasma enhances human PMNL chemotactic 
      response to zymosan-activated serum (ZAS) and 
      n-formyl-methionyl-leucyl-phenylalanine (FMLP). Maximal increase in chemotactic 
      migration was at nicotine concentration 1 mumol/l. Higher concentrations, above 
      0.1 mmol/l inhibited PMNL chemotactic response and spontaneous migration. 
      Nicotine also enhanced PMNL influx to the place of inflammation developed in the 
      mouse pleural cavity after injection of ZAS. The number of PMNL found in the 
      pleural cavity was 1.9-fold higher (p less than 0.001, n = 5) when animals were 
      pretreated with 0.15 mg of nicotine. However, this drug itself (concentrations of 
      0.1 mumol/l to 10 mmol/l) had weak chemotactic activity for PMNL. It seems that 
      the stimulatory action of nicotine on PMNL chemotaxis may be partly responsible 
      for increased PMNL numbers in the lower airways of cigarette smokers and 
      following formation of the elastase/antielastase imbalance in lung tissue.
FAU - Nowak, D
AU  - Nowak D
AD  - Department of Pneumonology and Allergology, Medical Academy, Lodz, Poland.
FAU - Ruta, U
AU  - Ruta U
FAU - Piasecka, G
AU  - Piasecka G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Pathol
JT  - Experimental pathology
JID - 8108218
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 9010-72-4 (Zymosan)
SB  - IM
MH  - Animals
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - Humans
MH  - In Vitro Techniques
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neutrophils/*drug effects
MH  - Nicotine/*pharmacology
MH  - Pulmonary Emphysema/etiology
MH  - Smoking/adverse effects
MH  - Zymosan/pharmacology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1016/s0232-1513(11)80218-5 [doi]
PST - ppublish
SO  - Exp Pathol. 1990;39(1):37-43. doi: 10.1016/s0232-1513(11)80218-5.