PMID- 23943507
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20211021
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 20
IP  - 11
DP  - 2014 Nov
TI  - Quality assessment of clinical research on liver cancer treated by intra-arterial 
      infusion of Chinese medicine.
PG  - 870-5
LID - 10.1007/s11655-013-1555-y [doi]
AB  - OBJECTIVE: To assess the methodological quality of clinical research on Chinese 
      medicine (CM) applied by intra-arterial infusion in treating primary liver cancer 
      (PLC). METHODS: Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, 
      and three Chinese databases, including Chinese BioMedical Database (CBM), China 
      National Knowledge Infrastructure (CNKI) and China Academic Journal (VIP) were 
      searched. Chinese articles were also searched manually in 16 journals. Two 
      reviewers independently selected studies, the quality of literatures were 
      assessed according to the Cochrane Collaboration method of quality assessment. 
      RESULTS: A total of 14 articles met the inclusion criteria for this review. Only 
      three of these articles described the randomization method used. None of the 
      studies was blinded. All of the articles didn't report the calculation of the 
      sample size. Only six studies mentioned adverse reactions. All of the studies 
      were of grade C according to the Cochrane Collaboration method. Six studies 
      reported results of survival, and only two of these reported better efficacy in 
      the treatment groups. CONCLUSIONS: The quality of studies concerned 
      intra-arterial infusion of CM in treating with PLC was poor and the exact effect 
      of these medicines still need evaluation. Well designed RCTs with large sample 
      sizes, adequate follow-up data and reliable methods of assessment are needed to 
      better appraise the real effect of CMs in the treatment of PLC patients.
FAU - Zhai, Xiao-Feng
AU  - Zhai XF
AD  - Department of Traditional Chinese Medicine, Changhai Hospital, the Second 
      Military Medical University, Shanghai, 200433, China.
FAU - Qiao, Cui-Xia
AU  - Qiao CX
FAU - Liu, Qun
AU  - Liu Q
FAU - Chen, Zhe
AU  - Chen Z
FAU - Ling, Chang-Quan
AU  - Ling CQ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130813
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
MH  - Biomedical Research/*standards
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - *Infusions, Intra-Arterial
MH  - Liver Neoplasms/*therapy
MH  - *Medicine, Chinese Traditional
MH  - Research Design
EDAT- 2013/08/15 06:00
MHDA- 2015/07/15 06:00
CRDT- 2013/08/15 06:00
PHST- 2011/11/30 00:00 [received]
PHST- 2013/08/15 06:00 [entrez]
PHST- 2013/08/15 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1007/s11655-013-1555-y [doi]
PST - ppublish
SO  - Chin J Integr Med. 2014 Nov;20(11):870-5. doi: 10.1007/s11655-013-1555-y. Epub 
      2013 Aug 13.