PMID- 23944963
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Print)
IS  - 0163-3864 (Linking)
VI  - 76
IP  - 8
DP  - 2013 Aug 23
TI  - Structures and potential antitumor activity of sesterterpenes from the marine 
      sponge Hyrtios communis.
PG  - 1492-7
LID - 10.1021/np400350k [doi]
AB  - The extract of marine sponge Hyrtios communis was found to inhibit activation of 
      the transcription factor hypoxia-inducible factor-1 (HIF-1) in T47D human breast 
      tumor cells. Bioassay-guided isolation led to the identification of six new (1-6) 
      and five previously reported (7-11) sesterterpene analogues and two unrelated 
      sesterterpenes. Two new sesterterpenes, thorectidaeolide A (1) and 
      4-acetoxythorectidaeolide A (2), and luffariellolide (11) were among the most 
      potent inhibitors of hypoxia (1% O(2))-induced HIF-1 activation (IC(5)(0) values of 
      3.2, 3.5, and 3.6 muM, respectively). Luffariellolide (11) exhibited a significant 
      level of cytotoxicity that mirrored its HIF-1 inhibitory activity. Neither 
      compound 1, compound 2, nor any of the other less active sesterterpenes 
      suppressed breast tumor T47D or MDA-MB-231 cell viability.
FAU - Li, Jun
AU  - Li J
AD  - Department of Pharmacognosy, School of Pharmacy, University of Mississippi, 
      University, Mississippi 38677, USA.
FAU - Du, Lin
AU  - Du L
FAU - Kelly, Michelle
AU  - Kelly M
FAU - Zhou, Yu-Dong
AU  - Zhou YD
FAU - Nagle, Dale G
AU  - Nagle DG
LA  - eng
GR  - C06 RR014503/RR/NCRR NIH HHS/United States
GR  - CA98787/CA/NCI NIH HHS/United States
GR  - C06 RR-14503-01/RR/NCRR NIH HHS/United States
GR  - R01 CA098787/CA/NCI NIH HHS/United States
GR  - R56 CA098787/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130814
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (4-acetoxythorectidaeolide A)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Sesterterpenes)
RN  - 0 (Terpenes)
RN  - 0 (thorectidaeolide A)
RN  - 111149-87-2 (luffariellolide)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/*isolation & purification/*pharmacology
MH  - Cell Survival/drug effects
MH  - Drug Screening Assays, Antitumor
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/antagonists & inhibitors
MH  - Inhibitory Concentration 50
MH  - Marine Biology
MH  - Molecular Structure
MH  - Oceans and Seas
MH  - Palau
MH  - Porifera/*chemistry
MH  - Sesterterpenes/chemistry/*isolation & purification/*pharmacology
MH  - Terpenes/*pharmacology
PMC - PMC3809078
MID - NIHMS516134
EDAT- 2013/08/16 06:00
MHDA- 2013/12/16 06:00
PMCR- 2014/08/23
CRDT- 2013/08/16 06:00
PHST- 2013/08/16 06:00 [entrez]
PHST- 2013/08/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2014/08/23 00:00 [pmc-release]
AID - 10.1021/np400350k [doi]
PST - ppublish
SO  - J Nat Prod. 2013 Aug 23;76(8):1492-7. doi: 10.1021/np400350k. Epub 2013 Aug 14.