PMID- 23945374
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20220317
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 209
IP  - 2
DP  - 2014 Jan 15
TI  - Associations between human leukocyte antigen class I variants and the 
      Mycobacterium tuberculosis subtypes causing disease.
PG  - 216-23
LID - 10.1093/infdis/jit443 [doi]
AB  - BACKGROUND:  The development of active tuberculosis disease has been shown to be 
      multifactorial. Interactions between host and bacterial genotype may influence 
      disease outcome, with some studies indicating the adaptation of M. tuberculosis 
      strains to specific human populations. Here we investigate the role of the human 
      leukocyte antigen (HLA) class I genes in this biological process. METHODS:  Three 
      hundred patients with tuberculosis from South Africa were typed for their HLA 
      class I alleles by direct sequencing. Mycobacterium tuberculosis genotype 
      classification was done by IS6110 restriction fragment length polymorphism 
      genotyping and spoligotyping. RESULTS:  We showed that Beijing strain occurred 
      more frequently in individuals with multiple disease episodes (P < .001) with the 
      HLA-B27 allele lowering the odds of having an additional episode (odds ratio, 
      0.21; P = .006). Associations were also identified for specific HLA types and 
      disease caused by the Beijing, LAM, LCC, and Quebec strains. HLA types were also 
      associated with disease caused by strains from the Euro-American or East Asian 
      lineages, and the frequencies of these alleles in their sympatric human 
      populations identified potential coevolutionary events between host and pathogen. 
      CONCLUSIONS:  This is the first report of the association of human HLA types and 
      M. tuberculosis strain genotype, highlighting that both host and pathogen 
      genetics need to be taken into consideration when studying tuberculosis disease 
      development.
FAU - Salie, Muneeb
AU  - Salie M
AD  - MRC Centre for Molecular and Cellular Biology and the DST/NRF Centre of 
      Excellence for Biomedical TB Research, Division of Molecular Biology and Human 
      Genetics, Stellenbosch University, Tygerberg.
FAU - van der Merwe, Lize
AU  - van der Merwe L
FAU - Moller, Marlo
AU  - Moller M
FAU - Daya, Michelle
AU  - Daya M
FAU - van der Spuy, Gian D
AU  - van der Spuy GD
FAU - van Helden, Paul D
AU  - van Helden PD
FAU - Martin, Maureen P
AU  - Martin MP
FAU - Gao, Xiao-Jiang
AU  - Gao XJ
FAU - Warren, Robin M
AU  - Warren RM
FAU - Carrington, Mary
AU  - Carrington M
FAU - Hoal, Eileen G
AU  - Hoal EG
LA  - eng
GR  - 053844/Z/98/Z/WT_/Wellcome Trust/United Kingdom
GR  - D43 TW000231/TW/FIC NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - 2 D43 TW000231 16/TW/FIC NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130814
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA Transposable Elements)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - DNA Transposable Elements
MH  - Female
MH  - Genotype
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Typing
MH  - Mycobacterium tuberculosis/*genetics/*immunology
MH  - Polymorphism, Restriction Fragment Length
MH  - Sequence Analysis, DNA
MH  - South Africa
MH  - Tuberculosis/*immunology/*microbiology
MH  - Young Adult
PMC - PMC3873786
OTO - NOTNLM
OT  - Mycobacterium tuberculosis
OT  - coadaptation
OT  - host-pathogen
OT  - human leukocyte antigens
OT  - susceptibility
OT  - tuberculosis
EDAT- 2013/08/16 06:00
MHDA- 2014/02/25 06:00
PMCR- 2015/01/15
CRDT- 2013/08/16 06:00
PHST- 2013/08/16 06:00 [entrez]
PHST- 2013/08/16 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
PHST- 2015/01/15 00:00 [pmc-release]
AID - jit443 [pii]
AID - 10.1093/infdis/jit443 [doi]
PST - ppublish
SO  - J Infect Dis. 2014 Jan 15;209(2):216-23. doi: 10.1093/infdis/jit443. Epub 2013 
      Aug 14.