PMID- 23946346
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 143
IP  - 10
DP  - 2013 Oct
TI  - Carbohydrate quality and quantity affect glucose and lipid metabolism during 
      weight regain in healthy men.
PG  - 1593-601
LID - 10.3945/jn.113.179390 [doi]
AB  - In this controlled, parallel-group feeding trial, we examined the impact of 
      carbohydrate (CHO) intake and glycemic index (GI) on glucose and lipid metabolism 
      during refeeding after weight loss. Healthy men (n = 32 total, age: 25.5 +/- 3.9 y, 
      BMI: 23.5 +/- 2.0 kg/m2) overconsumed diets containing either 50% or 65% CHO for 1 
      wk (+50% of energy requirements) and then underwent 3 wk of calorie restriction 
      (CR; -50%) followed by 2 wk of overconsuming (refeeding, +50%) the same diet but 
      with either a low or high GI (40 vs.70 during CR, 41 vs.74 during refeeding) so 
      that glycemic load (GL; dietary CHO content x GI) differed between groups during 
      all phases. Glucose profiles were assessed by continuous interstitial glucose 
      monitoring, insulin sensitivity (IS) by fasting blood sampling, oral glucose 
      tolerance test (OGTT) and hyperinsulinemic-euglycemic clamp, and liver fat by 
      MRI. Daytime area under the curve-glucose during refeeding was higher with high 
      compared with low GI (P = 0.01) and 65% compared with 50% CHO intake (P = 0.05) 
      and correlated with dietary GL (r = 0.71; P < 0.001). IS increased with CR and 
      decreased again with refeeding in all groups. The decrease in OGTT-derived IS was 
      greater with high- than with low-GI diets (-41 vs. -15%; P-interaction = 0.01) 
      and correlated with dietary GL during refeeding (r = -0.51; P < 0.01). Serum 
      triglycerides (TGs) and liver fat also improved with CR (-17 +/- 38 mg/dL and -1.1 
      +/- 1.3%; P < 0.05 and <0.001) and increased again with refeeding (+48 +/- 48 mg/dL 
      and +2.2 +/- 1.6%; P < 0.001). After refeeding, serum TGs and liver fat were 
      elevated above baseline values with 65% CHO intake only (+59.9 +/- 37.5 mg/dL and 
      +1.1 +/- 1.7%, P-interaction <0.001 and <0.05). In conclusion, a diet low in GI and 
      moderate in CHO content (i.e., low GL) may have health benefits by positively 
      affecting daylong glycemia, IS, and liver fat.
FAU - Lagerpusch, Merit
AU  - Lagerpusch M
AD  - Institute of Human Nutrition and Food Science, Christian-Albrechts University, 
      Kiel, Germany.
FAU - Enderle, Janna
AU  - Enderle J
FAU - Eggeling, Ben
AU  - Eggeling B
FAU - Braun, Wiebke
AU  - Braun W
FAU - Johannsen, Maike
AU  - Johannsen M
FAU - Pape, Detlef
AU  - Pape D
FAU - Muller, Manfred J
AU  - Muller MJ
FAU - Bosy-Westphal, Anja
AU  - Bosy-Westphal A
LA  - eng
SI  - ClinicalTrials.gov/NCT01737034
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130814
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - *Caloric Restriction
MH  - Dietary Carbohydrates/administration & dosage/*pharmacology/standards
MH  - Glucose Tolerance Test
MH  - *Glycemic Index
MH  - Humans
MH  - Hyperphagia
MH  - *Insulin Resistance
MH  - Lipid Metabolism/*drug effects
MH  - Liver/metabolism
MH  - Male
MH  - Triglycerides/blood
MH  - *Weight Gain
MH  - Weight Loss/physiology
MH  - Young Adult
EDAT- 2013/08/16 06:00
MHDA- 2013/11/15 06:00
CRDT- 2013/08/16 06:00
PHST- 2013/08/16 06:00 [entrez]
PHST- 2013/08/16 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
AID - S0022-3166(22)01319-0 [pii]
AID - 10.3945/jn.113.179390 [doi]
PST - ppublish
SO  - J Nutr. 2013 Oct;143(10):1593-601. doi: 10.3945/jn.113.179390. Epub 2013 Aug 14.