PMID- 23947347
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20130816
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 255
IP  - 1
DP  - 2013 Sep
TI  - The role of lung dendritic cell subsets in immunity to respiratory viruses.
PG  - 57-67
LID - 10.1111/imr.12100 [doi]
AB  - Viral infections are a common cause of acute respiratory disease. The clinical 
      course of infection and symptoms depend on the viral strain, the health status of 
      the host, and the immunological status of the host. Dendritic cells (DCs) play a 
      crucial role in recognizing and presenting viral antigens and in inducing 
      adaptive immune responses that clear the virus. Because the lung is continuously 
      exposed to the air, the lung is equipped with an elaborate network of DCs to 
      sense incoming foreign pathogens. Increasing knowledge on DC biology has informed 
      us that DCs are not a single cell type. In the steady state lung, three DC 
      subsets can be defined: CD11b(+) or CD103(+) conventional DCs and plasmacytoid 
      DCs. Upon inflammation, inflammatory monocyte-derived DCs are recruited to the 
      lung. It is only recently that tools became available to allow DC subsets to be 
      clearly studied. This review focuses on the activation of DCs and the function of 
      lung DCs in the context of respiratory virus infection and highlights some 
      cautionary points for interpreting older experiments.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Neyt, Katrijn
AU  - Neyt K
AD  - VIB Inflammation Research Center, Laboratory of Immunoregulation, Ghent, Belgium.
FAU - Lambrecht, Bart N
AU  - Lambrecht BN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Lung/*immunology/metabolism/*virology
MH  - Mice
MH  - Virus Diseases/*immunology/metabolism/virology
MH  - Viruses/*immunology
OTO - NOTNLM
OT  - airways
OT  - dendritic cell
OT  - lung
OT  - viral infection
EDAT- 2013/08/21 06:00
MHDA- 2014/04/09 06:00
CRDT- 2013/08/17 06:00
PHST- 2013/08/17 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
AID - 10.1111/imr.12100 [doi]
PST - ppublish
SO  - Immunol Rev. 2013 Sep;255(1):57-67. doi: 10.1111/imr.12100.