PMID- 23948417
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20130816
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 29
IP  - 8
DP  - 2013 Aug
TI  - [Changes and clinical significance of serum level of syndecan-4 protein in 
      patients with chronic congestive heart failure].
PG  - 866-9
AB  - OBJECTIVE: To detect serum level of syndecan-4 protein in patients with chronic 
      congestive heart failure (CHF) and investigate its correlation with New York 
      Heart Association (NYHA) class and echocardiographic parameters. METHODS: The 
      concentration of serum syndecan-4 protein was measured by enzyme-linked 
      immunosorbent assay (ELISA) in 40 patients with CHF and 40 healthy controls 
      (NCD), respectively. The parameters such as left ventricle ejection fraction 
      (LVEF), fraction shortening (FS), left ventricle end-diastolic diameter (LVDd), 
      left ventricle end-systolic diameter (LVDs), left ventricle end-diastolic volume 
      (LVEDV) and left ventricle end-systolic volume (LVESV) were detected by 
      echocardiography in 40 patients of CHF. Meanwhile, the patients' cardiac function 
      was graded according to NYHA class. RESULTS: The levels of serum syndecan-4 
      protein significantly increased in CHF group as compared with control group 
      (P<0.01). In CHF group, as the increased grading of NYHA cardiac function, the 
      levels of serum syndecan-4 protein significantly increased (P<0.05). The more 
      upgraded the NYHA grading, the higher level of serum syndecan-4 protein. In 
      bivariate correlations analysis showed that the level of serum syndecan-4 protein 
      was significantly negatively correlated with LVEF and FS (P<0.05) and was 
      significantly positively correlated with LVDd, LVDs, LVEDV and LVESV, 
      respectively (P<0.05). CONCLUSION: Serum syndecan-4 concentration significantly 
      increased in CHF patients, and it was closely correlated with NYHA class and left 
      ventricle function parameters, so the level of serum syndecan-4 protein may have 
      an important value in detection and surveillance of CHF.
FAU - Ma, Xiaoling
AU  - Ma X
AD  - Department of Cardiology, Southern Medical University, Guangzhou, China. 
      maxiaoling424@163.com
FAU - Ouyang, Ping
AU  - Ouyang P
FAU - Zhang, Zhineng
AU  - Zhang Z
FAU - Lai, Wenyan
AU  - Lai W
FAU - Xu, Dingli
AU  - Xu D
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (SDC4 protein, human)
RN  - 0 (Syndecan-4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Failure/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Syndecan-4/*blood
EDAT- 2013/08/21 06:00
MHDA- 2013/11/08 06:00
CRDT- 2013/08/17 06:00
PHST- 2013/08/17 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Aug;29(8):866-9.