PMID- 23948463
OWN - NLM
STAT- MEDLINE
DCOM- 20140129
LR  - 20180714
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 120
IP  - 12
DP  - 2013 Dec
TI  - Association between perifoveal hyperfluorescence and serous retinal detachment in 
      diabetic macular edema.
PG  - 2596-2603
LID - S0161-6420(13)00516-2 [pii]
LID - 10.1016/j.ophtha.2013.06.014 [doi]
AB  - OBJECTIVE: To study the association between the fluorescence levels on 
      fluorescein angiography images and the characteristics on spectral-domain optical 
      coherence tomography (SD OCT) images in diabetic macular edema (DME). DESIGN: 
      Retrospective, observational, cross-sectional study. PARTICIPANTS: One hundred 
      sixty-seven consecutive eyes of 116 patients with diabetic retinopathy for whom 
      FA and SD OCT were performed on the same day. METHODS: Fluorescein angiography 
      using the Heidelberg Retina Angiograph 2 and OCT images using Spectralis OCT 
      (Heidelberg Engineering, Heidelberg, Germany) were obtained. The leakage of 
      fluorescein dye in each subfield of the Early Treatment Diabetic Retinopathy 
      Study (ETDRS) grid was quantified and defined as fluorescence levels, which were 
      compared with the retinal thickness and foveal pathomorphologic features 
      evaluated by SD OCT. MAIN OUTCOME MEASURES: The relationship between fluorescence 
      levels and the foveal pathomorphologic features on SD OCT images. RESULTS: One 
      hundred twelve (67%) eyes with center-involved DME had significantly higher 
      fluorescence levels in all subfields of the ETDRS grid than 55 (33%) eyes without 
      DME. Fluorescence levels were correlated modestly with the retinal thickness in 
      individual subfields in eyes with center-involved DME. Thirty-seven eyes with 
      foveal serous retinal detachment (SRD) had greater retinal thickness in all 
      subfields and higher levels of fluorescence in most subfields, except the 
      superior subfield of the inner ring. After adjusting for the central retinal 
      thickness using multivariate analyses, eyes with SRD had significantly (P = 
      0.0085) higher fluorescence levels in the nasal subfield of the inner ring and 
      the superior, nasal, and inferior subfields of the outer ring (P = 0.0117, P = 
      0.0020, and P = 0.0017, respectively). However, the fluorescence levels in any 
      subfields of the inner or outer ring did not differ significantly between eyes 
      with and without foveal cystoid spaces. CONCLUSIONS: The correlation between the 
      fluorescence levels and retinal thickness suggests that the vascular 
      hyperpermeability in the perifovea contributes to the pathogenesis of foveal SRD 
      in DME.
CI  - Copyright (c) 2013 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Murakami, Tomoaki
AU  - Murakami T
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan. Electronic address: mutomo@kuhp.kyoto-u.ac.jp.
FAU - Uji, Akihito
AU  - Uji A
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Ogino, Ken
AU  - Ogino K
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Unoki, Noriyuki
AU  - Unoki N
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Horii, Takahiro
AU  - Horii T
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Yoshitake, Shin
AU  - Yoshitake S
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Nishijima, Kazuaki
AU  - Nishijima K
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20130812
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - TPY09G7XIR (Fluorescein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood-Retinal Barrier
MH  - Capillary Permeability
MH  - Cross-Sectional Studies
MH  - Diabetic Retinopathy/*complications/metabolism
MH  - Female
MH  - Fluorescein/metabolism
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Macular Edema/*complications/metabolism
MH  - Male
MH  - Middle Aged
MH  - Retinal Detachment/*diagnosis/*etiology/metabolism
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
EDAT- 2013/08/21 06:00
MHDA- 2014/01/30 06:00
CRDT- 2013/08/17 06:00
PHST- 2013/02/02 00:00 [received]
PHST- 2013/06/05 00:00 [revised]
PHST- 2013/06/05 00:00 [accepted]
PHST- 2013/08/17 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/01/30 06:00 [medline]
AID - S0161-6420(13)00516-2 [pii]
AID - 10.1016/j.ophtha.2013.06.014 [doi]
PST - ppublish
SO  - Ophthalmology. 2013 Dec;120(12):2596-2603. doi: 10.1016/j.ophtha.2013.06.014. 
      Epub 2013 Aug 12.