PMID- 23949197
OWN - NLM
STAT- MEDLINE
DCOM- 20140328
LR  - 20220321
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 38
IP  - 10
DP  - 2013 Oct
TI  - Possible role of oxidative stress and brain derived neurotrophic factor in 
      triazophos induced cognitive impairment in rats.
PG  - 2136-47
LID - 10.1007/s11064-013-1122-0 [doi]
AB  - Triazophos, O,O-diethyl-1-H-1,2,4-triazol-3-yl phosphorothioate, (TZ) is an 
      organophosphate pesticide widely used as an insecticide in agriculture fields, 
      however, its adverse effects on cognitive function remain unknown till date. The 
      present study was designed to identify the effect of TZ on cognitive function in 
      order to gain an insight into the molecular mechanism(s) probably involved in TZ 
      induced toxicity. Wistar male albino rats were orally administered with TZ at 8.2 
      mg/kg bw daily for 30 days. Cognitive function was assessed by evaluating step 
      down latency (SDL) in passive avoidance apparatus, transfer latency (TL) on 
      elevated plus maze and escape latency (EL) using morris water maze. The 
      biochemical changes, in terms of malondialdehyde (MDA), reduced glutathione (GSH) 
      and brain derived neurotrophic factor (BDNF) levels were evaluated in hippocampi 
      regions. Relative mRNA expression and protein expression of BDNF were also 
      evaluated. The results demonstrated that rats treated with TZ showed 
      significantly (p < 0.01) reduced SDL and prolonged TL and EL as compared to 
      control group rats. Moreover, significantly low (p < 0.01) mRNA expression and 
      protein levels (p < 0.001) of BDNF, increased MDA and reduced GSH levels were 
      observed in TZ treated rats. The study concludes that chronic exposure to TZ 
      significantly impairs the learning and memory which may be attributed to the 
      significantly reduced mRNA and protein expression of BDNF in hippocampus. 
      Moreover, BDNF is negatively correlated to MDA levels and positively correlated 
      to GSH levels. Hence, it can be suggested that interplay between BDNF and 
      oxidative stress plays an important role in mediating the toxic effects of TZ.
FAU - Jain, Smita
AU  - Jain S
AD  - Environmental Biochemistry and Molecular Biology Laboratory, Department of 
      Biochemistry, University College of Medical Sciences and GTB Hospital (University 
      of Delhi), Dilshad Garden, Delhi, 110095, India.
FAU - Banerjee, Basu Dev
AU  - Banerjee BD
FAU - Ahmed, Rafat Sultana
AU  - Ahmed RS
FAU - Arora, Vinod Kumar
AU  - Arora VK
FAU - Mediratta, Pramod Kumari
AU  - Mediratta PK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130815
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insecticides)
RN  - 0 (Organothiophosphates)
RN  - 0 (RNA, Messenger)
RN  - 0 (Triazoles)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 6099J8L0EE (triazophos)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*physiology
MH  - Cognition/drug effects
MH  - Cognition Disorders/*chemically induced
MH  - Glutathione/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Insecticides/toxicity
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Organothiophosphates/*toxicity
MH  - *Oxidative Stress
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Triazoles/*toxicity
EDAT- 2013/08/21 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/08/17 06:00
PHST- 2013/04/18 00:00 [received]
PHST- 2013/07/30 00:00 [accepted]
PHST- 2013/06/28 00:00 [revised]
PHST- 2013/08/17 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - 10.1007/s11064-013-1122-0 [doi]
PST - ppublish
SO  - Neurochem Res. 2013 Oct;38(10):2136-47. doi: 10.1007/s11064-013-1122-0. Epub 2013 
      Aug 15.