PMID- 23952049
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20220331
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 29
IP  - 11
DP  - 2013 Nov
TI  - Association study of the TNF-alpha -1031T/C and VEGF +450G/C polymorphisms with 
      susceptibility to endometriosis.
PG  - 974-7
LID - 10.3109/09513590.2013.824956 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha), a multifunctional proinflammatory cytokine, and 
      vascular endothelial growth factor (VEGF), a major mediator of angiogenesis and 
      vascular permeability, have been investigated in endometriosis patients of 
      different populations. This study was carried out to investigate whether the two 
      polymorphisms, TNF-alpha -1031T/C and VEGF +450G/C are associated with susceptibility 
      to endometriosis in an Iranian population. Totally, 135 women with diagnosis of 
      endometriosis and 173 women with no evidence of the disease were included in this 
      study. The -1031T/C and +450G/C polymorphisms were assessed by PCR-RFLP analysis, 
      using the two restriction enzymes BbsI and BsmFI, respectively. The frequencies 
      of the TNF-alpha -1031TC genotype (p = 0.038) and the -1031 C allele (p = 0.048) were 
      significantly lower in patients than control group. In contrast, no significant 
      differences in the genotype and allele frequencies of the VEGF +450G/C 
      polymorphism were found between the case and control groups. Our results suggest 
      that the TNF-alpha -1031T/C polymorphism was associated with susceptibility to 
      endometriosis in Iranian population, and the -1301C allele may have a protective 
      role in development of endometriosis; On the contrary, we find no association 
      between the VEGF +450G/C polymorphism and risk of endometriosis.
FAU - Saliminejad, Kioomars
AU  - Saliminejad K
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, Academic 
      Center for Education Culture and Research (ACECR) , Tehran , Iran and.
FAU - Memariani, Toktam
AU  - Memariani T
FAU - Ardekani, Ali M
AU  - Ardekani AM
FAU - Kamali, Koorosh
AU  - Kamali K
FAU - Edalatkhah, Haleh
AU  - Edalatkhah H
FAU - Pahlevanzadeh, Zhamak
AU  - Pahlevanzadeh Z
FAU - Khorram Khorshid, Hamid Reza
AU  - Khorram Khorshid HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130816
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (5' Untranslated Regions)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - 5' Untranslated Regions
MH  - Adult
MH  - Alleles
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Endometriosis/complications/*genetics/metabolism/physiopathology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Infertility, Female/etiology
MH  - Iran
MH  - Middle Aged
MH  - Overweight/complications
MH  - *Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
MH  - Vascular Endothelial Growth Factor A/*genetics/metabolism
MH  - Young Adult
EDAT- 2013/08/21 06:00
MHDA- 2014/05/06 06:00
CRDT- 2013/08/20 06:00
PHST- 2013/08/20 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
AID - 10.3109/09513590.2013.824956 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2013 Nov;29(11):974-7. doi: 10.3109/09513590.2013.824956. 
      Epub 2013 Aug 16.