PMID- 23954720
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20131015
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 206
IP  - 1
DP  - 2013 Oct 25
TI  - Protective effects of diphenyl diselenide in a mouse model of brain toxicity.
PG  - 18-26
LID - S0009-2797(13)00203-2 [pii]
LID - 10.1016/j.cbi.2013.08.002 [doi]
AB  - Interest in organoselenide chemistry and biochemistry has increased in the past 
      three decades, mainly due to their chemical and biological activities. Here, we 
      investigated the protective effect of the organic selenium compound diphenyl 
      diselenide (PhSe)2 (5 mumol/kg), in a mouse model of methylmercury (MeHg)-induced 
      brain toxicity. Our group has previously demonstrated that the oral and repeated 
      administration (21 days) of MeHg (40 mg/L) induced MeHg brain accumulation at 
      toxic concentrations, and a pattern of severe cortical and cerebellar biochemical 
      and behavioral. In order to assess neurotoxicity, the neurochemical parameters, 
      namely, mitochondrial complexes I, II, II-III and IV, glutathione peroxidase 
      (GPx) and glutathione reductase (GR) activities, the content of thiobarbituric 
      acid-reactive substances (TBA-RS), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 
      brain-derived neurotrophic factor (BDNF), as well as, metal deposition were 
      investigated in mouse cerebral cortex. Cortical neurotoxicity induced by brain 
      MeHg deposition was characterized by the reduction of complexes I, II, and IV 
      activities, reduction of GPx and increased GR activities, increased TBA-RS and 
      8-OHdG content, and reduced BDNF levels. The daily treatment with (PhSe)2 was 
      able to counteract the inhibitory effect of MeHg on mitochondrial activities, the 
      increased oxidative stress parameters, TBA-RS and 8-OHdG levels, and the 
      reduction of BDNF content. The observed protective (PhSe)2 effect could be linked 
      to its antioxidant properties and/or its ability to reduce MeHg deposition in 
      brain, which was here histochemically corroborated. Altogether, these data 
      indicate that (PhSe)2 could be consider as a neuroprotectant compound to be 
      tested under neurotoxicity.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Glaser, Viviane
AU  - Glaser V
AD  - Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal 
      de Santa Catarina, Florianopolis, SC, Brazil.
FAU - Moritz, Bettina
AU  - Moritz B
FAU - Schmitz, Ariana
AU  - Schmitz A
FAU - Dafre, Alcir Luiz
AU  - Dafre AL
FAU - Nazari, Evelise Maria
AU  - Nazari EM
FAU - Rauh Muller, Yara Maria
AU  - Rauh Muller YM
FAU - Feksa, Luciane
AU  - Feksa L
FAU - Straliottoa, Marcos Raniel
AU  - Straliottoa MR
FAU - de Bem, Andreza Fabro
AU  - de Bem AF
FAU - Farina, Marcelo
AU  - Farina M
FAU - da Rocha, Joao Batista Teixeira
AU  - da Rocha JB
FAU - Latini, Alexandra
AU  - Latini A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130814
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Benzene Derivatives)
RN  - 0 (Methylmercury Compounds)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Organoselenium Compounds)
RN  - 1666-13-3 (diphenyldiselenide)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/*pharmacology
MH  - Benzene Derivatives/chemistry/*pharmacology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Cerebral Cortex/*drug effects/metabolism/pathology
MH  - *Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Screening Assays, Antitumor
MH  - Male
MH  - Methylmercury Compounds/chemistry/pharmacology
MH  - Mice
MH  - Neuroprotective Agents/chemistry/*pharmacology
MH  - Organoselenium Compounds/chemistry/*pharmacology
MH  - Structure-Activity Relationship
OTO - NOTNLM
OT  - Diphenyl diselenide
OT  - Methylmercury
OT  - Neurotoxicity
OT  - Oxidative stress
OT  - Respiratory chain complexes
EDAT- 2013/08/21 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/08/20 06:00
PHST- 2012/11/13 00:00 [received]
PHST- 2013/07/24 00:00 [revised]
PHST- 2013/08/03 00:00 [accepted]
PHST- 2013/08/20 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - S0009-2797(13)00203-2 [pii]
AID - 10.1016/j.cbi.2013.08.002 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2013 Oct 25;206(1):18-26. doi: 10.1016/j.cbi.2013.08.002. 
      Epub 2013 Aug 14.