PMID- 23955460
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20130819
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 140
IP  - 3
DP  - 2013 Sep
TI  - Acute hepatitis with periportal confluent necrosis associated with human 
      herpesvirus 6 infection in liver transplant patients.
PG  - 403-9
LID - 10.1309/AJCP0FWI2XAHECBJ [doi]
AB  - OBJECTIVES: To correlate human herpesvirus 6 (HHV-6) viral load with pathologic 
      features in graft acute hepatitis of unknown origin. METHODS: Liver frozen 
      samples from 26 patients with graft hepatitis of unknown origin were available 
      for HHV-6 DNA quantification. RESULTS: In 10 (38.5%) of 26 liver samples, HHV-6 
      DNA was detectable, with a median viral load of 3.84 log10 copies/10(6) cells. 
      Confluent periportal necrosis was observed in 4 of 10 patients and associated 
      with high viral load. These 4 patients responded to antiviral therapy. Mild 
      unspecific hepatitis was observed in 4 patients with low intragraft viral load 
      and in 2 patients with high viral load in a context of deep immunosuppression. 
      Patients with HHV-6-negative graft hepatitis disclosed lobular 
      necrotico-inflammatory activity without periportal necrosis. CONCLUSIONS: Our 
      study provides data supporting the pathogenic role of HHV-6 for liver allografts. 
      The presence of confluent periportal necrosis could be a clue for prompt 
      diagnosis of HHV-6-induced graft hepatitis.
FAU - Buyse, Sophie
AU  - Buyse S
AD  - AP-HP, Hopital Paul Brousse, Centre Hepato-Biliaire, Villejuif, France.
FAU - Roque-Afonso, Anne-Marie
AU  - Roque-Afonso AM
FAU - Vaghefi, Parissa
AU  - Vaghefi P
FAU - Gigou, Michele
AU  - Gigou M
FAU - Dussaix, Elisabeth
AU  - Dussaix E
FAU - Duclos-Vallee, Jean-Charles
AU  - Duclos-Vallee JC
FAU - Samuel, Didier
AU  - Samuel D
FAU - Guettier, Catherine
AU  - Guettier C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - DNA, Viral
MH  - Female
MH  - Hepatitis/*pathology/virology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Liver/*pathology/virology
MH  - Liver Transplantation/*pathology
MH  - Male
MH  - Middle Aged
MH  - Roseolovirus Infections/*pathology/virology
MH  - Viral Load
OTO - NOTNLM
OT  - Graft dysfunction
OT  - Graft hepatitis
OT  - Human herpesvirus 6
OT  - Liver transplantation
EDAT- 2013/08/21 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/08/20 06:00
PHST- 2013/08/20 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - 140/3/403 [pii]
AID - 10.1309/AJCP0FWI2XAHECBJ [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2013 Sep;140(3):403-9. doi: 10.1309/AJCP0FWI2XAHECBJ.