PMID- 23957213
OWN - NLM
STAT- MEDLINE
DCOM- 20140718
LR  - 20131119
IS  - 1600-0609 (Electronic)
IS  - 0902-4441 (Linking)
VI  - 91
IP  - 6
DP  - 2013 Dec
TI  - 14q32 translocations and 13q14 deletions are common cytogenetic abnormalities in 
      POEMS syndrome.
PG  - 490-6
LID - 10.1111/ejh.12189 [doi]
AB  - OBJECTIVE: POEMS syndrome is a paraneoplastic syndrome characterized by 
      polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell (PC) 
      proliferative disease, and skin changes. Although chromosomal aberrations have 
      been found and extensively described for other PC disorders, whether POEMS 
      syndrome shares similar cytogenetic profiles has been rarely reported. In this 
      study, we aimed to clarify the cytogenetic abnormalities of patients with POEMS 
      syndrome in our center. METHODS: Purified CD138(+) PCs from bone marrow samples 
      of twenty patients with POEMS syndrome were studied by interphase fluorescence in 
      situ hybridization (FISH). FISH results were analyzed for an association between 
      cytogenetic changes and clinical features. RESULTS: A majority of patients (65%) 
      were found to bear cytogenetic aberrations commonly seen in multiple myeloma. The 
      14q32 (IGH) translocation was observed in 45% of the cases and included the 
      t(4;14) and t(11;14) translocation (15% and 25% of the cases, respectively). In 
      addition, 25% of the patients had deletions of 13q14 and 20% had an amplification 
      of 1q21. No significant correlation between clinical features with cytogenetic 
      abnormalities was observed, although patients with IGH translocations were more 
      likely to exhibit papilledema (P = 0.018). CONCLUSION: Cytogenetic aberrations in 
      POEMS syndrome were similar to other PC dyscrasias, but at different percentages.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kang, Wen-Ying
AU  - Kang WY
AD  - Department of Hematology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Shen, Kai-Ni
AU  - Shen KN
FAU - Duan, Ming-Hui
AU  - Duan MH
FAU - Zhang, Wei
AU  - Zhang W
FAU - Cao, Xin-Xin
AU  - Cao XX
FAU - Zhou, Dao-Bin
AU  - Zhou DB
FAU - Li, Jian
AU  - Li J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131010
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow/pathology
MH  - Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 13
MH  - *Chromosomes, Human, Pair 14
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - POEMS Syndrome/diagnosis/*genetics
MH  - *Translocation, Genetic
OTO - NOTNLM
OT  - POEMS syndrome
OT  - cytogenetic abnormalities
OT  - fluorescence in situ hybridization
EDAT- 2013/08/21 06:00
MHDA- 2014/07/19 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/08/03 00:00 [accepted]
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2014/07/19 06:00 [medline]
AID - 10.1111/ejh.12189 [doi]
PST - ppublish
SO  - Eur J Haematol. 2013 Dec;91(6):490-6. doi: 10.1111/ejh.12189. Epub 2013 Oct 10.